Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.48 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.40 |
| ▸ | F13A1 | P00488 | 1/20 | 0.39 |
| ▸ | TGM2 | P21980 | 1/20 | 0.39 |
| ▸ | TGM1 | P22735 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | TDO2 | P48775 | 1/20 | 0.38 |
| ▸ | IDO2 | Q6ZQW0 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.38 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL903894 | 0.94 | GPR119 (0.49) | GPR119GRIN1GRIN2BIDO1TDO2 | |
| SCHEMBL903888 | 0.83 | ALDH1A1 (0.44) | GPR119IDO1TDO2IDO2KDM4E | |
| SCHEMBL903880 | 0.83 | KDM4E (0.42) | GPR119KDM4EALDH1A1 | |
| SCHEMBL904003 | 0.83 | ALDH1A1 (0.44) | GPR119IDO1TDO2IDO2KDM4E | |
| SCHEMBL23091766 | 0.76 | GPR119 (0.48) | GPR119GRIN1GRIN2BNR1H2PDE4B | |
| SCHEMBL30013316 | 0.76 | GPR119 (0.48) | GPR119GRIN1GRIN2BNR1H2PDE4B | |
| SCHEMBL27151214 | 0.75 | GPR119 (0.47) | GPR119GRIN1GRIN2BNR1H2PDE4B | |
| SCHEMBL27151216 | 0.75 | GPR119 (0.47) | GPR119GRIN1GRIN2BNR1H2PDE4B | |
| SCHEMBL10190043 | 0.71 | UTS2R (0.44) | IDO1TDO2IDO2SMN1; SMN2PDE4B | |
| SCHEMBL322856 | 0.71 | PDE4B (0.45) | KDM4ESMN1; SMN2PDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012041158-A1 | TRICYCLIC COMPOUND, PREPARATION METHOD AND PHARMACEUTICAL USE THEREOF | 上海恒瑞医药有限公司 (CN) | 2012-04-05 | — | — | WO | disclosed |