Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | UTS2R | Q9UKP6 | 16/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL903888 | 0.90 | ALDH1A1 (0.44) | KDM4EALDH1A1UTS2RGPR119 | |
| SCHEMBL903894 | 0.90 | GPR119 (0.49) | KDM4EALDH1A1GPR119 | |
| SCHEMBL904003 | 0.90 | ALDH1A1 (0.44) | KDM4EALDH1A1UTS2RGPR119 | |
| SCHEMBL903892 | 0.83 | GPR119 (0.48) | KDM4EALDH1A1GPR119 | |
| SCHEMBL1005985 | 0.77 | UTS2R (0.44) | UTS2RGPR119 | |
| SCHEMBL30013049 | 0.77 | HDAC1 (0.45) | GPR119 | |
| SCHEMBL904096 | 0.77 | NPC1 (0.40) | KDM4EALDH1A1UTS2RGPR119 | |
| SCHEMBL12239153 | 0.76 | GPR119 (0.60) | KDM4EALDH1A1GPR119 | |
| SCHEMBL12263204 | 0.75 | UTS2R (0.57) | UTS2R | |
| SCHEMBL31203093 | 0.74 | ALDH1A1 (0.46) | ALDH1A1GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012041158-A1 | TRICYCLIC COMPOUND, PREPARATION METHOD AND PHARMACEUTICAL USE THEREOF | 上海恒瑞医药有限公司 (CN) | 2012-04-05 | — | — | WO | disclosed |