SCHEMBL9039031

SCHEMBL9039031

CC(C)OC(=O)CN1C(=O)C(NC(=O)Nc2ccccc2Cl)C=C(c2ccccc2)c2ccccc21

nearest known ligand 0.50

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
CCKBR P32239 14/20 0.50
ALDH1A1 P00352 1/20 0.45
AGTR1 P30556 1/20 0.45
TP53 P04637 1/20 0.42
POLB P06746 1/20 0.42
DRD2 P14416 1/20 0.38
ADRA1D P25100 1/20 0.38
ADRA1A P35348 1/20 0.38
ADRA1B P35368 1/20 0.38
CCKAR P32238 3/20 0.38
ANPEP P15144 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9039449 0.90 ALDH1A1 (0.46) CCKBRALDH1A1AGTR1CCKARANPEP
SCHEMBL9048213 0.89 CCKBR (0.51) CCKBRALDH1A1AGTR1POLBDRD2
SCHEMBL9041314 0.88 CCKBR (0.56) CCKBRALDH1A1AGTR1
SCHEMBL9041968 0.88 CCKBR (0.50) CCKBRTP53POLB
SCHEMBL9039643 0.86 ALDH1A1 (0.42) CCKBRALDH1A1AGTR1TP53POLB
SCHEMBL9040664 0.86 CCKBR (0.51) CCKBRALDH1A1AGTR1CCKAR
SCHEMBL9039782 0.85 CCKBR (0.49) CCKBRALDH1A1AGTR1CCKAR
SCHEMBL9043273 0.84 CCKBR (0.51) CCKBRALDH1A1AGTR1POLBCCKAR
SCHEMBL9042659 0.83 CCKBR (0.51) CCKBRTP53POLB
SCHEMBL9041225 0.83 CCKBR (0.71) CCKBRALDH1A1TP53POLBCCKAR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0703222-A1 3-AMINOAZEPINE COMPOUND AND PHARMACEUTICAL USE THEREOF YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) 1996-03-27 EP disclosed