Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 4/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | ATF4 | P18848 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL904207 | 0.78 | GPR119 (0.60) | POLBTDP1BLMALDH1A1PKM | |
| SCHEMBL904063 | 0.78 | GPR119 (0.66) | ALDH1A1PKMGPR119 | |
| SCHEMBL15486250 | 0.75 | GPR119 (0.49) | POLBTDP1BLMALDH1A1PKM | |
| SCHEMBL12987784 | 0.75 | GPR119 (0.49) | POLBTDP1BLMALDH1A1PKM | |
| SCHEMBL13195458 | 0.72 | POLB (0.44) | POLBTDP1BLMALDH1A1PKM | |
| SCHEMBL4202083 | 0.70 | CYP19A1 (0.63) | POLBTDP1BLMALDH1A1PKM | |
| SCHEMBL4207158 | 0.70 | POLB (0.60) | POLBTDP1BLMALDH1A1PKM | |
| Hydrochloric Acid SCHEMBL13735667 | 0.68 | TDP1 (0.44) | POLBTDP1BLMALDH1A1PKM | |
| Hydrochloric Acid SCHEMBL13735668 | 0.68 | TDP1 (0.44) | POLBTDP1BLMALDH1A1PKM | |
| SCHEMBL8381009 | 0.68 | NOTUM (0.51) | POLBTDP1BLMALDH1A1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012041158-A1 | TRICYCLIC COMPOUND, PREPARATION METHOD AND PHARMACEUTICAL USE THEREOF | 上海恒瑞医药有限公司 (CN) | 2012-04-05 | — | — | WO | disclosed |