Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 17/20 | 0.66 |
| ▸ | NAMPT | P43490 | 1/20 | 0.47 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL903975 | 0.91 | GPR119 (0.56) | GPR119NAMPTCHEK2ALDH1A1 | |
| SCHEMBL904065 | 0.84 | GPR119 (0.52) | GPR119NAMPTCHEK2ALDH1A1 | |
| SCHEMBL13194903 | 0.80 | GPR119 (0.58) | GPR119CHEK2ALDH1A1PKM | |
| SCHEMBL10080587 | 0.78 | USP2 (0.66) | GPR119ALDH1A1 | |
| SCHEMBL903904 | 0.78 | POLB (0.44) | GPR119ALDH1A1PKM | |
| SCHEMBL31574923 | 0.77 | GPR119 (0.68) | GPR119 | |
| SCHEMBL904207 | 0.76 | GPR119 (0.60) | GPR119ALDH1A1PKM | |
| SCHEMBL15511389 | 0.76 | GPR119 (0.57) | GPR119CHEK2ALDH1A1 | |
| SCHEMBL15495788 | 0.76 | GPR119 (0.57) | GPR119CHEK2ALDH1A1 | |
| SCHEMBL14297532 | 0.74 | GPR119 (0.69) | GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012041158-A1 | TRICYCLIC COMPOUND, PREPARATION METHOD AND PHARMACEUTICAL USE THEREOF | 上海恒瑞医药有限公司 (CN) | 2012-04-05 | — | — | WO | disclosed |