Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 11/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL903904 | 0.78 | POLB (0.44) | GPR119ALDH1A1PKMPOLBRXFP1 | |
| SCHEMBL904063 | 0.76 | GPR119 (0.66) | GPR119ALDH1A1PKM | |
| SCHEMBL3371738 | 0.74 | GPR119 (0.60) | GPR119POLBMAPTSMN1; SMN2 | |
| SCHEMBL1950704 | 0.72 | GPR119 (0.72) | GPR119ALDH1A1POLBRXFP1MAPT | |
| SCHEMBL3688791 | 0.72 | GPR119 (0.66) | GPR119ALDH1A1PKMPOLBRXFP1 | |
| SCHEMBL21397888 | 0.71 | GPR119 (0.73) | GPR119ALDH1A1POLBRXFP1KCNH2 | |
| SCHEMBL903908 | 0.71 | GPR119 (0.52) | GPR119POLBRXFP1MAPTBLM | |
| Mbx-2982 SCHEMBL1118326 | 0.70 | GPR119 (1.00) | GPR119ALDH1A1 | |
| SCHEMBL1118366 | 0.70 | GPR119 (0.71) | GPR119ALDH1A1POLBRXFP1KCNH2 | |
| SCHEMBL14316382 | 0.70 | GPR119 (0.64) | GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012041158-A1 | TRICYCLIC COMPOUND, PREPARATION METHOD AND PHARMACEUTICAL USE THEREOF | 上海恒瑞医药有限公司 (CN) | 2012-04-05 | — | — | WO | disclosed |