Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.66 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.61 |
| ▸ | NPC1 | O15118 | 3/20 | 0.60 |
| ▸ | RAB9A | P51151 | 3/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.56 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL591955 | 0.91 | POLB (0.58) | POLBDDAH1NPC1RAB9ALMNA | |
| SCHEMBL593247 | 0.91 | POLB (0.58) | POLBDDAH1NPC1RAB9ALMNA | |
| SCHEMBL230157 | 0.83 | POLB (0.84) | POLBDDAH1NPC1RAB9APDE10A | |
| SCHEMBL1918882 | 0.82 | NPC1 (0.67) | POLBDDAH1NPC1RAB9ALMNA | |
| SCHEMBL29749508 | 0.80 | DDAH1 (0.72) | POLBDDAH1NPC1RAB9APDE10A | |
| SCHEMBL612507 | 0.80 | DDAH1 (0.72) | POLBDDAH1NPC1RAB9APDE10A | |
| SCHEMBL8948422 | 0.80 | NPC1 (0.71) | POLBNPC1RAB9ALMNAPDE10A | |
| SCHEMBL7078925 | 0.80 | MAPT (0.63) | POLBDDAH1NPC1RAB9ALMNA | |
| SCHEMBL6801751 | 0.80 | POLB (0.57) | POLBDDAH1NPC1RAB9ALMNA | |
| SCHEMBL7854448 | 0.80 | POLB (0.92) | POLBDDAH1NPC1RAB9APDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0393574-B1 | Hexitol derivatives | KYOWA HAKKO KOGYO KK (JP) | 1996-01-31 | — | — | EP | disclosed |
| US-5053408-A | Cardiovascular disorders | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1991-10-01 | — | — | US | disclosed |
| EP-0393574-A2 | Hexitol derivatives | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1990-10-24 | — | — | EP | disclosed |