Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6801589 | 0.99 | POLB (0.55) | POLBMAPTHTTALDH1A1DDAH1 | |
| SCHEMBL7078925 | 0.85 | MAPT (0.63) | POLBMAPTHTTALDH1A1DDAH1 | |
| SCHEMBL9039049 | 0.80 | POLB (0.66) | POLBMAPTALDH1A1DDAH1NPC1 | |
| SCHEMBL23870902 | 0.78 | MAPT (0.57) | POLBMAPTHTTALDH1A1NPC1 | |
| SCHEMBL26784996 | 0.78 | MAPT (0.57) | POLBMAPTHTTALDH1A1CHRM1 | |
| SCHEMBL26785029 | 0.77 | CHRM1 (0.57) | POLBMAPTHTTALDH1A1NPC1 | |
| SCHEMBL25475182 | 0.77 | ALDH1A1 (0.60) | POLBMAPTHTTALDH1A1NPC1 | |
| SCHEMBL23870887 | 0.77 | CYP1A2 (0.57) | POLBMAPTHTTALDH1A1CHRM1 | |
| SCHEMBL230157 | 0.77 | POLB (0.84) | POLBMAPTDDAH1NPC1RAB9A | |
| SCHEMBL25475139 | 0.75 | ALDH1A1 (0.65) | POLBMAPTHTTALDH1A1CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004066999-A1 | COMPOSITIONS CONTAINING 2, 2’ -METHYLENEBISBENZIMIDAZOLE DERIVATIVES FOR TREATING ISCHEMIA-RELATED NEURONAL DAMAGE | ELAN PHARMACEUTICALS, INC. (US) | 2004-08-12 | — | — | WO | disclosed |