Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 3/20 | 0.57 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.57 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.57 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.57 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.57 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.57 |
| ▸ | DRD1 | P21728 | 10/20 | 0.57 |
| ▸ | HTR2C | P28335 | 2/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8904492 | 1.00 | ADRA2A (0.57) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| Bromide SCHEMBL7309876 | 0.99 | DRD1 (0.56) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| Bromide SCHEMBL9038836 | 0.99 | DRD1 (0.56) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL9669172 | 0.74 | ADRA2A (0.81) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL8902336 | 0.74 | ADRA2A (0.81) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| Bromide SCHEMBL7508700 | 0.73 | ADRA2A (0.78) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL7447221 | 0.73 | DRD1 (1.00) | ADRA2AADRA2BADRA2CDRD1HTR2C | |
| SCHEMBL9038117 | 0.73 | DRD1 (1.00) | ADRA2AADRA2BADRA2CDRD1HTR2C | |
| SCHEMBL10380336 | 0.73 | DRD1 (1.00) | ADRA2AADRA2BADRA2CDRD1HTR2C | |
| SCHEMBL10380050 | 0.73 | DRD1 (1.00) | ADRA2AADRA2BADRA2CDRD1HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0474767-B1 | DOPAMINE AGONISTS | ABBOTT LAB (US) | 1996-02-21 | — | — | EP | claimed |
| EP-0474767-A4 | DOPAMINE AGONISTS | — | 1992-07-08 | — | — | EP | claimed |
| EP-0474767-A1 | DOPAMINE AGONISTS. | ABBOTT LAB (US) | 1992-03-18 | — | — | EP | claimed |
| EP-0474767-B1 | DOPAMINE AGONISTS | ABBOTT LAB (US) | 1996-02-21 | — | — | EP | disclosed |
| EP-0474767-A4 | DOPAMINE AGONISTS | — | 1992-07-08 | — | — | EP | disclosed |
| EP-0474767-A1 | DOPAMINE AGONISTS. | ABBOTT LAB (US) | 1992-03-18 | — | — | EP | disclosed |