Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A known ✓ | P08913 | 3/20 | 0.78 |
| ▸ | ADRA2B known ✓ | P18089 | 3/20 | 0.78 |
| ▸ | ADRA2C known ✓ | P18825 | 3/20 | 0.78 |
| ▸ | ADRA1D known ✓ | P25100 | 3/20 | 0.78 |
| ▸ | ADRA1A known ✓ | P35348 | 3/20 | 0.78 |
| ▸ | ADRA1B known ✓ | P35368 | 3/20 | 0.78 |
| ▸ | DRD1 | P21728 | 3/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9669172 | 0.98 | ADRA2A (0.81) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL8902336 | 0.98 | ADRA2A (0.81) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL8816707 | 0.83 | ADRA2A (0.58) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL9549176 | 0.83 | ADRA2A (0.58) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL8411065 | 0.75 | ADRA2A (0.51) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| Bromide SCHEMBL9038836 | 0.75 | DRD1 (0.56) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| Bromide SCHEMBL7309876 | 0.75 | DRD1 (0.56) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL15824544 | 0.75 | ADRA2A (0.47) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL15839876 | 0.73 | KDM4C (0.46) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL21091917 | 0.73 | ADRB2 (0.49) | ADRA2AADRA2BADRA2CADRA1DADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996038435-A1 | DOPAMINE AGONISTS | ABBOTT LABORATORIES (US) | 1996-12-05 | — | — | WO | disclosed |