Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.38 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9041380 | 0.91 | TP53 (0.42) | ALOX5SMN1; SMN2GAARAB9ANPC1 | |
| SCHEMBL9039541 | 0.88 | ALOX5 (0.43) | ALOX5SMN1; SMN2GAARAB9ANPC1 | |
| SCHEMBL6988751 | 0.86 | ALOX5 (0.49) | ALOX5SMN1; SMN2 | |
| SCHEMBL6990085 | 0.85 | SMN1; SMN2 (0.43) | ALOX5SMN1; SMN2GAARAB9ANPC1 | |
| SCHEMBL9039965 | 0.83 | TSHR (0.53) | KDM4ETSHR | |
| SCHEMBL9039948 | 0.82 | SMN1; SMN2 (0.40) | ALOX5SMN1; SMN2GAARAB9ANPC1 | |
| SCHEMBL3784364 | 0.81 | HPGD (0.49) | SMN1; SMN2RAB9ANPC1KDM4ETSHR | |
| SCHEMBL9037903 | 0.73 | TSHR (0.51) | KDM4ETSHR | |
| SCHEMBL13222147 | 0.73 | KDM4E (0.54) | GAAKDM4EPOLB | |
| SCHEMBL27037027 | 0.73 | NAMPT (0.39) | SMN1; SMN2RAB9ANPC1KDM4ETSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0441349-B1 | Pyrroloazepine derivatives | SUNTORY LTD (JP) | 1996-01-03 | — | — | EP | disclosed |
| US-5416082-A | Antiserotonine agents | SUNTORY LIMITED (JP) | 1995-05-16 | — | — | US | disclosed |
| US-5391731-A | Useful therapeutics for circulatory diseases | SUNTORY LIMITED (JP) | 1995-02-21 | — | — | US | disclosed |
| US-5206239-A | Cardiovascular disorders | SUNTORY LIMITED (JP) | 1993-04-27 | — | — | US | disclosed |
| EP-0441349-A1 | Pyrroloazepine derivatives | SUNTORY LIMITED (JP) | 1991-08-14 | — | — | EP | disclosed |