Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | LTA4H | P09960 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.38 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9039345 | 0.85 | ALOX5 (0.42) | SMN1; SMN2GAAALOX5NPC1RAB9A | |
| SCHEMBL9041380 | 0.84 | TP53 (0.42) | SMN1; SMN2GAAALOX5NPC1RAB9A | |
| SCHEMBL9039948 | 0.83 | SMN1; SMN2 (0.40) | SMN1; SMN2GAAALOX5NPC1RAB9A | |
| SCHEMBL9039541 | 0.82 | ALOX5 (0.43) | SMN1; SMN2GAAALOX5LTA4HNPC1 | |
| SCHEMBL6988130 | 0.81 | TSHR (0.56) | TSHR | |
| SCHEMBL6988751 | 0.80 | ALOX5 (0.49) | SMN1; SMN2ALOX5LTA4H | |
| SCHEMBL7002275 | 0.75 | SMN1; SMN2 (0.40) | SMN1; SMN2ALOX5LTA4HNPC1RAB9A | |
| SCHEMBL13222147 | 0.74 | KDM4E (0.54) | GAA | |
| SCHEMBL5160927 | 0.73 | RAB9A (0.49) | SMN1; SMN2GAANPC1RAB9ATSHR | |
| SCHEMBL31717390 | 0.72 | MMP2 (0.45) | GAATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0551527-B1 | PYRROLOAZEPINE DERIVATIVE | SUNTORY LTD (JP) | 2003-04-02 | — | — | EP | disclosed |
| EP-0441349-B1 | Pyrroloazepine derivatives | SUNTORY LTD (JP) | 1996-01-03 | — | — | EP | disclosed |
| US-5416082-A | Antiserotonine agents | SUNTORY LIMITED (JP) | 1995-05-16 | — | — | US | disclosed |
| US-5397780-A | Antiserotonine, hypotensive, congestive heart failure | SUNTORY LIMITED (JP) | 1995-03-14 | — | — | US | disclosed |
| US-5391731-A | Useful therapeutics for circulatory diseases | SUNTORY LIMITED (JP) | 1995-02-21 | — | — | US | disclosed |
| EP-0551527-A1 | PYRROLOAZEPINE DERIVATIVE | SUNTORY LIMITED (JP) | 1993-07-21 | — | — | EP | disclosed |
| US-5206239-A | Cardiovascular disorders | SUNTORY LIMITED (JP) | 1993-04-27 | — | — | US | disclosed |
| EP-0441349-A1 | Pyrroloazepine derivatives | SUNTORY LIMITED (JP) | 1991-08-14 | — | — | EP | disclosed |