Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 4/20 | 0.40 |
| ▸ | GABRA5 | P31644 | 4/20 | 0.40 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.40 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.40 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.40 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 4/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27896031 | 0.82 | KDM4E (0.43) | SMN1; SMN2RECQLMAPK10ALDH1A1MAPT | |
| SCHEMBL8352120 | 0.79 | APOBEC3A (0.50) | SMN1; SMN2ALDH1A1MAPTGABRA1GABRA5 | |
| SCHEMBL5192788 | 0.76 | ALDH1A1 (0.44) | SMN1; SMN2RECQLMAPK10ALDH1A1MAPT | |
| SCHEMBL4125342 | 0.74 | TNF (0.40) | SMN1; SMN2RECQLMAPK10ALDH1A1MAPT | |
| SCHEMBL7951572 | 0.74 | ALDH1A1 (0.41) | SMN1; SMN2RECQLALDH1A1MAPTGABRA1 | |
| SCHEMBL7950773 | 0.74 | NPC1 (0.42) | SMN1; SMN2ALDH1A1MAPTCYP1A2KDM4E | |
| SCHEMBL31553574 | 0.74 | ALDH1A1 (0.49) | ALDH1A1MAPTNPSR1CYP1A2CYP2D6 | |
| SCHEMBL9039147 | 0.74 | NPC1 (0.50) | SMN1; SMN2RECQLMAPK10ALDH1A1NPC1 | |
| SCHEMBL9038215 | 0.74 | HPGD (0.53) | SMN1; SMN2RECQLMAPK10ALDH1A1MAPT | |
| SCHEMBL10568713 | 0.74 | ALDH1A1 (0.51) | SMN1; SMN2RECQLMAPK10ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0393574-B1 | Hexitol derivatives | KYOWA HAKKO KOGYO KK (JP) | 1996-01-31 | — | — | EP | disclosed |
| US-5053408-A | Cardiovascular disorders | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1991-10-01 | — | — | US | disclosed |