Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.43 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 4/20 | 0.41 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.40 |
| ▸ | ELANE | P08246 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12151786 | 0.89 | SLC6A11 (0.46) | KIF11KMT2AMAPTPPARAMEN1 | |
| SCHEMBL28021468 | 0.86 | KIF11 (0.42) | KIF11CYP2C19HIF1AHDAC6HDAC3 | |
| SCHEMBL9041026 | 0.84 | KCNN4 (0.53) | KIF11CYP2C19HIF1AHDAC6HDAC3 | |
| SCHEMBL12149872 | 0.84 | KIF11 (0.47) | KIF11CYP2C19CYP2C9KMT2AMAPT | |
| SCHEMBL28021471 | 0.81 | KIF11 (0.44) | KIF11CYP2C19HIF1AHDAC6HDAC3 | |
| SCHEMBL20295113 | 0.80 | TSHR (0.41) | KIF11CYP2C19HIF1AHDAC6HDAC3 | |
| SCHEMBL17410560 | 0.78 | CHRM2 (0.42) | KIF11CYP2C19HIF1AHDAC6HDAC3 | |
| SCHEMBL2512972 | 0.78 | CHRM2 (0.39) | KIF11CYP2C19HIF1AHDAC6HDAC3 | |
| SCHEMBL8850056 | 0.78 | KIF11 (0.52) | KIF11CYP2C19HIF1AKCNN4ELANE | |
| SCHEMBL12151785 | 0.77 | KCNN4 (0.45) | KIF11KMT2AMAPTKCNN4MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250282803-A1 | DIDEHYDRO-3'-DEOXY-4'-ETHYNYLTHYMIDINES AND RELATED COMPOUNDS AND THEIR USE IN TREATING MEDICAL CONDITIONS | ROME THERAPEUTICS, INC. | 2025-09-11 | — | — | US | disclosed |
| EP-4511381-A1 | DIDEHYDRO-3'-DEOXY-4'-ETHYNYLTHYMIDINES AND RELATED COMPOUNDS AND THEIR USE IN TREATING MEDICAL CONDITIONS | Rome Therapeutics, Inc. (US) | 2025-02-26 | — | — | EP | disclosed |
| CN-119403815-A | Didehydro-3 '-deoxy-4' -ethynyl thymidine and related compounds and their use in treating medical conditions | 罗梅治疗股份有限公司 | 2025-02-07 | — | — | CN | disclosed |
| WO-2023205786-A1 | DIDEHYDRO-3'-DEOXY-4'-ETHYNYLTHYMIDINES AND RELATED COMPOUNDS AND THEIR USE IN TREATING MEDICAL CONDITIONS | ROME THERAPEUTICS, INC. (US) | 2023-10-26 | — | — | WO | disclosed |
| EP-3559011-B1 | ANTIVIRAL ESTER PRODRUGS OF TENOFOVIR | MERCK SHARP & DOHME (US) | 2022-04-13 | — | — | EP | disclosed |
| EP-3559011-B1 | ANTIVIRAL ESTER PRODRUGS OF TENOFOVIR | MERCK SHARP & DOHME (US) | 2022-04-13 | — | — | EP | disclosed |
| CN-110099912-B | Antiviral tenofovir aliphatic ester prodrug | 默沙东公司 | 2021-10-15 | — | — | CN | disclosed |
| US-10519159-B2 | Antiviral aliphatic ester prodrugs of tenofovir | MERCK SHARP & DOHME CORP. (US) | 2019-12-31 | — | — | US | disclosed |
| US-10519159-B2 | Antiviral aliphatic ester prodrugs of tenofovir | MERCK SHARP & DOHME CORP. (US) | 2019-12-31 | — | — | US | disclosed |
| CN-110099912-A | Antiviral tenofovir aliphatic ester prodrug | 默沙东公司 | 2019-08-06 | — | — | CN | disclosed |
| US-20180179208-A1 | ANTIVIRAL ALIPHATIC ESTER PRODRUGS OF TENOFOVIR | MERCK SHARP & DOHME CORP. (US) | 2018-06-28 | — | — | US | disclosed |
| US-20180179208-A1 | ANTIVIRAL ALIPHATIC ESTER PRODRUGS OF TENOFOVIR | MERCK SHARP & DOHME CORP. (US) | 2018-06-28 | — | — | US | disclosed |
| US-20180179208-A1 | ANTIVIRAL ALIPHATIC ESTER PRODRUGS OF TENOFOVIR | MERCK SHARP & DOHME CORP. (US) | 2018-06-28 | — | — | US | disclosed |
| WO-2018119013-A1 | ANTIVIRAL ALIPHATIC ESTER PRODRUGS OF TENOFOVIR | MERCK SHARP & DOHME CORP. (US) | 2018-06-28 | — | — | WO | disclosed |
| EP-0535192-B1 | NOVEL DNA GYRASE INHIBITORS, PROCESS FOR THEIR MANUFACTURE AND PHARMACEUTICAL PREPARATIONS CONTAINING SAME | HOFFMANN LA ROCHE (CH) | 1996-06-19 | — | — | EP | disclosed |
| US-5486466-A | ENZYME INHIBITORS | HOFFMANN-LA ROCHE INC. (US) | 1996-01-23 | — | — | US | disclosed |
| US-5399741-A | DNA gyrase inhibitors, process for their manufacture and pharmaceutical preparations containing same | HOFFMANN-LA ROCHE INC. (US) | 1995-03-21 | — | — | US | disclosed |
| US-5294609-A | Microbiocides | HOFFMANN-LAROCHE INC. (US) | 1994-03-15 | — | — | US | disclosed |
| EP-0535192-A1 | NOVEL DNA GYRASE INHIBITORS, PROCESS FOR THEIR MANUFACTURE AND PHARMACEUTICAL PREPARATIONS CONTAINING SAME. | HOFFMANN LA ROCHE (CH) | 1993-04-07 | — | — | EP | disclosed |
| WO-1992018490-A1 | NOVEL DNA GYRASE INHIBITORS, PROCESS FOR THEIR MANUFACTURE AND PHARMACEUTICAL PREPARATIONS CONTAINING SAME | F. HOFFMANN-LA ROCHE AG (CH) | 1992-10-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10519159-B2 | Antiviral aliphatic ester prodrugs of tenofovir | TYMP, PNP, GART | KIF11 4544/4885CYP2C19 113/4885HIF1A 2195/4885 |
| US-20250282803-A1 | DIDEHYDRO-3'-DEOXY-4'-ETHYNYLTHYMIDINES AND RELATED COMPOUNDS AND THEIR USE IN TREATING MEDICAL CONDITIONS | DTYMK, DCK, POLK | KIF11 2714/4885CYP2C19 762/4885HIF1A 378/4885 |
| US-20180179208-A1 | ANTIVIRAL ALIPHATIC ESTER PRODRUGS OF TENOFOVIR | TYMP, PNP, GART | KIF11 4576/4885CYP2C19 118/4885HIF1A 2115/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.