Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 3/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 7/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL904071 | 0.89 | GPR119 (0.33) | GRM2GPR119 | |
| SCHEMBL904069 | 0.88 | GPR119 (0.33) | ACACBGRM2GPR119 | |
| SCHEMBL904032 | 0.82 | ACACB (0.37) | ACACBGRM2GPR119MEN1KMT2A | |
| SCHEMBL904171 | 0.75 | GPR119 (0.41) | GRM2GPR119 | |
| SCHEMBL10068007 | 0.71 | GPR119 (0.52) | GPR119MEN1KMT2ANPC1TP53 | |
| SCHEMBL10067592 | 0.71 | GPR119 (0.36) | ACACBGRM2GPR119 | |
| SCHEMBL904073 | 0.71 | GPR119 (0.36) | ACACBGRM2GPR119 | |
| SCHEMBL904041 | 0.69 | GPR119 (0.35) | ACACBGPR119 | |
| SCHEMBL903979 | 0.68 | MKNK1 (0.35) | ACACBGPR119 | |
| SCHEMBL904109 | 0.68 | GPR119 (0.45) | GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012041158-A1 | TRICYCLIC COMPOUND, PREPARATION METHOD AND PHARMACEUTICAL USE THEREOF | 上海恒瑞医药有限公司 (CN) | 2012-04-05 | — | — | WO | disclosed |