Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | PKM | P14618 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MCOLN3 | Q8TDD5 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
| ▸ | KAT6A | Q92794 | 2/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9038709 | 0.85 | LMNA (0.42) | LMNAL3MBTL1PKMKMT2AMCOLN3 | |
| SCHEMBL30156675 | 0.83 | F2 (0.43) | LMNAL3MBTL1PKMTDP1GAA | |
| SCHEMBL30156583 | 0.83 | F2 (0.43) | LMNAL3MBTL1PKMTDP1GAA | |
| SCHEMBL15000836 | 0.81 | LMNA (0.55) | LMNAL3MBTL1PKMKMT2AMCOLN3 | |
| SCHEMBL6115267 | 0.81 | LMNA (0.55) | LMNAL3MBTL1PKMKMT2AMCOLN3 | |
| SCHEMBL15009954 | 0.80 | SCN9A (0.36) | LMNAHTT | |
| SCHEMBL2270234 | 0.79 | CA1 (0.43) | KMT2ATSHRTDP1MAPK1SMN1; SMN2 | |
| SCHEMBL9442565 | 0.78 | L3MBTL1 (0.56) | LMNAL3MBTL1PKMKMT2AMCOLN3 | |
| SCHEMBL2880572 | 0.77 | L3MBTL1 (0.55) | LMNAL3MBTL1PKMKMT2AMCOLN3 | |
| SCHEMBL25703510 | 0.76 | ALDH1A1 (0.42) | LMNAL3MBTL1GAAHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0402989-B1 | Antifungal 4-[4-[4-[4-[[2-(2,4-difluorophenyl)-2-(1H-azolylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]triazolones and imidazolones | JANSSEN PHARMACEUTICA NV (BE) | 1996-04-03 | — | — | EP | disclosed |
| EP-0331232-B1 | 5-lipoxygenase inhibiting 4-(4-phenyl-1-piperazinyl)phenols | JANSSEN PHARMACEUTICA NV (BE) | 1994-05-18 | — | — | EP | disclosed |
| US-5075309-A | For prevention and treatment of fungal diseases in mammals | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-12-24 | — | — | US | disclosed |
| EP-0402989-A2 | Antifungal 4-[4-[4-[4-[[2-(2,4-difluorophenyl)-2-(1H-azolylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]triazolones and imidazolones | JANSSEN PHARMACEUTICA N.V. (BE) | 1990-12-19 | — | — | EP | disclosed |
| US-4931444-A | FOR LEUKOTRIENE-MEDIATED DISEASES AND DISORDERS | JANSSEN PHARMACEUTICA N.V. (BE) | 1990-06-05 | — | — | US | disclosed |
| EP-0331232-A2 | 5-lipoxygenase inhibiting 4-(4-phenyl-1-piperazinyl)phenols | JANSSEN PHARMACEUTICA N.V. (BE) | 1989-09-06 | — | — | EP | disclosed |