Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | APEX1 | P27695 | 1/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.40 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9143111 | 1.00 | MAPT (0.43) | MAPTLMNAKMT2AMEN1APEX1 | |
| SCHEMBL9040570 | 0.85 | AKR1C3 (0.47) | MAPTLMNAKMT2AMEN1AKR1C3 | |
| SCHEMBL9148465 | 0.85 | AKR1C3 (0.47) | MAPTLMNAKMT2AMEN1AKR1C3 | |
| SCHEMBL9040255 | 0.83 | KMT2A (0.47) | MAPTLMNAKMT2AMEN1RAB9A | |
| SCHEMBL9078233 | 0.83 | KMT2A (0.47) | MAPTLMNAKMT2AMEN1RAB9A | |
| SCHEMBL9078732 | 0.81 | CYP1A2 (0.50) | MAPTKMT2AMEN1RAB9AALDH1A1 | |
| SCHEMBL9037814 | 0.81 | CYP1A2 (0.50) | MAPTKMT2AMEN1RAB9AALDH1A1 | |
| SCHEMBL9039470 | 0.80 | ALDH1A1 (0.46) | MAPTLMNAKMT2AMEN1RAB9A | |
| SCHEMBL9141472 | 0.80 | ALDH1A1 (0.46) | MAPTLMNAKMT2AMEN1RAB9A | |
| SCHEMBL9039669 | 0.80 | TRPA1 (0.49) | MAPTAKR1C3RAB9AALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5585382-A | ANTICARCINOGENIC AGENTS | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-12-17 | — | — | US | disclosed |
| EP-0705250-A1 | BIS-IMIDE POLYCYCLIC AND HETEROCYCLIC CHROMOPHORES USEFUL AS TUMORICIDALS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-04-10 | — | — | EP | disclosed |
| US-5416089-A | Antitumor agent | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1995-05-16 | — | — | US | disclosed |
| WO-1995000490-A1 | BIS-IMIDE POLYCYCLIC AND HETEROCYCLIC CHROMOPHORES USEFUL AS TUMORICIDALS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1995-01-05 | — | — | WO | disclosed |