Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB1 | Q9H4B7 | 8/20 | 0.55 |
| ▸ | TUBB4A | P04350 | 6/20 | 0.50 |
| ▸ | TUBB | P07437 | 6/20 | 0.50 |
| ▸ | TUBA3C | P0DPH7 | 6/20 | 0.50 |
| ▸ | TUBA1B | P68363 | 6/20 | 0.50 |
| ▸ | TUBA4A | P68366 | 6/20 | 0.50 |
| ▸ | TUBB4B | P68371 | 6/20 | 0.50 |
| ▸ | TUBB3 | Q13509 | 6/20 | 0.50 |
| ▸ | TUBB2A | Q13885 | 6/20 | 0.50 |
| ▸ | TUBB8 | Q3ZCM7 | 6/20 | 0.50 |
| ▸ | TUBA3E | Q6PEY2 | 6/20 | 0.50 |
| ▸ | TUBA1A | Q71U36 | 6/20 | 0.50 |
| ▸ | TUBA1C | Q9BQE3 | 6/20 | 0.50 |
| ▸ | TUBB6 | Q9BUF5 | 6/20 | 0.50 |
| ▸ | TUBB2B | Q9BVA1 | 6/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8934082 | 0.87 | TUBB1 (0.50) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL902497 | 0.83 | TUBB1 (0.53) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL12963218 | 0.82 | TUBB4A (0.63) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL9041895 | 0.80 | TUBB1 (0.46) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL31445795 | 0.80 | HTR2A (0.55) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL9041661 | 0.80 | TUBB1 (0.46) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| Floverine SCHEMBL2109150 | 0.79 | ALDH1A1 (0.52) | CYP3A4NPC1SMN1; SMN2ALDH1A1RECQL | |
| SCHEMBL1573275 | 0.79 | ALDH1A1 (0.52) | CYP3A4NPC1SMN1; SMN2ALDH1A1RECQL | |
| SCHEMBL4374860 | 0.78 | CA2 (0.57) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL10438523 | 0.78 | NPC1 (0.46) | TUBB1TUBB4ATUBBTUBA3CTUBA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0512352-B1 | Substituted carboxylic acid derivatives | HOFFMANN LA ROCHE (CH) | 1996-03-27 | — | — | EP | disclosed |
| US-5344843-A | Carnitine acryltransferase enzyme inhibitors as antiischemic agents and for cardiovascular disorders | HOFFMAN-LA ROCHE INC. (US) | 1994-09-06 | — | — | US | disclosed |
| EP-0301751-B1 | PYRIDINIUM DERIVATIVES, THEIR PRODUCTION AND USE | Takeda Chemical Industries, Ltd. (JP) | 1993-03-10 | — | — | EP | disclosed |
| EP-0512352-A2 | Substituted carboxylic acid derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1992-11-11 | — | — | EP | disclosed |
| US-4962113-A | PLATELET ACTIVATING FACTOR ANTAGONISTS | TAKEDA CHEMICAL INDUSTRIES, LTD (JP) | 1990-10-09 | — | — | US | disclosed |
| EP-0301751-A1 | Pyridinium derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1989-02-01 | — | — | EP | disclosed |