Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.52 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.52 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.52 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.52 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.49 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9043226 | 0.93 | PDE4A (0.49) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9041440 | 0.90 | PTGES (0.49) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9044061 | 0.90 | AGTR1 (0.49) | PDE4APDE4BPDE4CPDE4DAGTR1 | |
| SCHEMBL9043443 | 0.90 | AGTR1 (0.53) | PDE4APDE4BPDE4CPDE4DAGTR1 | |
| SCHEMBL9057014 | 0.89 | AGTR1 (0.48) | PDE4APDE4BPDE4CPDE4DAGTR1 | |
| SCHEMBL9039382 | 0.89 | PDE4A (0.48) | PDE4APDE4BPDE4CPDE4DAGTR1 | |
| SCHEMBL9041914 | 0.86 | AGTR1 (0.55) | PDE4APDE4BPDE4CPDE4DAGTR1 | |
| SCHEMBL9043272 | 0.86 | AGTR1 (0.46) | PDE4APDE4BPDE4CPDE4DAGTR1 | |
| SCHEMBL9044726 | 0.85 | AGTR1 (0.51) | AGTR1AGTR2 | |
| SCHEMBL9039836 | 0.84 | AGTR1 (0.51) | AGTR1AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0515535-A4 | ANGIOTENSIN II ANTAGONISTS INCORPORATING A SUBSTITUTED BENZYL ELEMENT | MERCK & CO INC (US) | 1996-01-17 | — | — | EP | claimed |
| EP-0515535-A4 | ANGIOTENSIN II ANTAGONISTS INCORPORATING A SUBSTITUTED BENZYL ELEMENT | MERCK & CO INC (US) | 1996-01-17 | — | — | EP | disclosed |