Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 2/20 | 0.48 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.48 |
| ▸ | PDE4A | P27815 | 1/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
| ▸ | PTGES | O14684 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9044061 | 0.96 | AGTR1 (0.49) | AGTR1AGTR2PDE4APDE4BPDE4C | |
| SCHEMBL9043443 | 0.93 | AGTR1 (0.53) | AGTR1AGTR2PDE4APDE4BPDE4C | |
| SCHEMBL9043272 | 0.93 | AGTR1 (0.46) | AGTR1AGTR2PDE4APDE4BPDE4C | |
| SCHEMBL9041440 | 0.92 | PTGES (0.49) | PDE4APDE4BPDE4CPDE4DPTGES | |
| SCHEMBL9041908 | 0.89 | PDE4A (0.52) | AGTR1AGTR2PDE4APDE4BPDE4C | |
| SCHEMBL9057017 | 0.88 | AGTR1 (0.49) | AGTR1AGTR2PDE4APDE4BPDE4C | |
| SCHEMBL9040731 | 0.86 | AGTR1 (0.46) | AGTR1AGTR2 | |
| SCHEMBL9059082 | 0.84 | AGTR2 (0.43) | AGTR1AGTR2 | |
| SCHEMBL9044068 | 0.84 | AGTR1 (0.49) | AGTR1AGTR2PDE4APDE4BPDE4C | |
| SCHEMBL9039659 | 0.82 | AGTR1 (0.43) | AGTR1AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0515535-A4 | ANGIOTENSIN II ANTAGONISTS INCORPORATING A SUBSTITUTED BENZYL ELEMENT | MERCK & CO INC (US) | 1996-01-17 | — | — | EP | disclosed |