Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.57 |
| ▸ | HTR2C | P28335 | 9/20 | 0.56 |
| ▸ | QDPR | P09417 | 3/20 | 0.55 |
| ▸ | HTR6 | P50406 | 2/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | HTR7 | P34969 | 1/20 | 0.45 |
| ▸ | KHK | P50053 | 3/20 | 0.44 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.42 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16434840 | 0.87 | HTR2C (0.57) | SIGMAR1HTR2CQDPRHTR6HTR2A | |
| Hydrochloric Acid SCHEMBL16422718 | 0.86 | HTR2C (0.58) | SIGMAR1HTR2CQDPRHTR6HTR2A | |
| SCHEMBL3383939 | 0.85 | HTR2C (0.62) | SIGMAR1HTR2CQDPRHTR6HTR2A | |
| SCHEMBL14956908 | 0.85 | QDPR (0.60) | SIGMAR1HTR2CQDPRHTR6HTR7 | |
| Hydrochloric Acid SCHEMBL6371753 | 0.83 | HTR2C (0.64) | SIGMAR1HTR2CQDPRHTR6HTR2A | |
| SCHEMBL6586022 | 0.82 | SIGMAR1 (0.52) | SIGMAR1HTR2CQDPRHTR6HTR2A | |
| SCHEMBL6589127 | 0.82 | SIGMAR1 (0.50) | SIGMAR1HTR2CQDPRHTR6HTR2A | |
| SCHEMBL2269930 | 0.81 | SIGMAR1 (0.67) | SIGMAR1HTR2CQDPRHTR6 | |
| SCHEMBL904201 | 0.81 | HTR2C (0.49) | SIGMAR1HTR2CQDPRHTR6HTR2A | |
| SCHEMBL17397697 | 0.81 | QDPR (0.73) | SIGMAR1HTR2CQDPRHTR6HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0958287-B2 | SULFAMIDE-METALLOPROTEASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2008-04-09 | — | — | EP | disclosed |
| EP-0958287-B1 | SULFAMIDE-METALLOPROTEASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2002-09-11 | — | — | EP | disclosed |
| US-6376506-B1 | REACTING SULFAMOYL OXAZOLIDONE WITH (1,2,3,4)-TETRAHYDRO-BETA-CARBOLINE TO FORM INHIBITOR; USED TO TREAT ARTHRITIS, OSTEOPOROSIS, PERIODONTAL DISEASE, CARDIOVASCULAR DISEASES, MULTIPLE SCLEROSIS, AND TUMORS | SYNTEX (U.S.A.) LLC | 2002-04-23 | — | — | US | disclosed |