Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | PDE9A | O76083 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 4/20 | 0.35 |
| ▸ | MAOA | P21397 | 3/20 | 0.35 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.34 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.34 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.34 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9311703 | 0.70 | DYRK1A (0.35) | LRRK2MCL1IKBKBCHUK | |
| SCHEMBL4914070 | 0.67 | HSP90AB1 (0.43) | LRRK2CYP11B2ARALDH1A1HSP90AB1 | |
| SCHEMBL5562294 | 0.67 | LRRK2 (0.50) | LRRK2MCL1ARALDH1A1KDM4E | |
| SCHEMBL942 | 0.66 | TSHR (0.46) | LRRK2ARPDE9AALDH1A1KDM4E | |
| SCHEMBL14154903 | 0.66 | MCL1 (0.41) | LRRK2MCL1ALDH1A1KDM4ENPSR1 | |
| SCHEMBL12670780 | 0.65 | CHUK (0.47) | LRRK2MCL1ALDH1A1KDM4ENPSR1 | |
| SCHEMBL17051410 | 0.64 | ALDH1A1 (0.52) | LRRK2CYP11B1CYP11B2ARPDE9A | |
| SCHEMBL9040621 | 0.64 | MAOA (0.47) | LRRK2MCL1CYP11B1CYP11B2AR | |
| SCHEMBL10536003 | 0.64 | ALDH1A1 (0.46) | CYP11B1CYP11B2ARPDE9AALDH1A1 | |
| SCHEMBL10533916 | 0.62 | ESR2 (0.51) | ALDH1A1KDM4ESMN1; SMN2NPSR1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0480204-B1 | Imidazole derivatives, potent and selective antagonists of angiotensin II receptor | FUJISAWA PHARMACEUTICAL CO (JP) | 1996-03-20 | — | — | EP | disclosed |