Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.68 |
| ▸ | MEN1 | O00255 | 3/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.68 |
| ▸ | TP53 | P04637 | 3/20 | 0.65 |
| ▸ | HPGD | P15428 | 3/20 | 0.65 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.65 |
| ▸ | POLB | P06746 | 3/20 | 0.65 |
| ▸ | FAAH | O00519 | 2/20 | 0.64 |
| ▸ | HPSE | Q9Y251 | 2/20 | 0.60 |
| ▸ | AURKA | O14965 | 2/20 | 0.58 |
| ▸ | PARP1 | P09874 | 1/20 | 0.58 |
| ▸ | DHODH | Q02127 | 1/20 | 0.58 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6258154 | 0.86 | HPSE (0.81) | KDM4EALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL14027836 | 0.84 | AURKA (0.62) | KDM4EALDH1A1SMN1; SMN2HPGDFAAH | |
| SCHEMBL2244254 | 0.81 | KDM4E (1.00) | KDM4EALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL2740026 | 0.81 | AURKA (0.69) | KDM4EALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL9043285 | 0.80 | KDM4E (0.61) | KDM4EALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL2740027 | 0.79 | AURKA (0.61) | KDM4EALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL14027835 | 0.77 | KDM4E (0.65) | KDM4EALDH1A1SMN1; SMN2HPGDFAAH | |
| SCHEMBL7393911 | 0.76 | AURKA (0.66) | FAAHHPSEAURKAPARP1PRMT5 | |
| SCHEMBL4057633 | 0.76 | MEN1 (0.53) | KDM4EALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL29066590 | 0.74 | LMNA (0.60) | KDM4EALDH1A1KMT2AHPGDHPSE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0700906-A1 | Heterocyclic derivatives of N-phenylamides | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-03-13 | — | — | EP | claimed |
| US-5496826-A | ANTICONVULSANTS, MELATONERGIC AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-03-05 | — | — | US | claimed |
| EP-0700906-A1 | Heterocyclic derivatives of N-phenylamides | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-03-13 | — | — | EP | disclosed |
| US-5496826-A | ANTICONVULSANTS, MELATONERGIC AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-03-05 | — | — | US | disclosed |