Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.84 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.84 |
| ▸ | RAB9A | P51151 | 2/20 | 0.84 |
| ▸ | NPC1 | O15118 | 2/20 | 0.84 |
| ▸ | PKM | P14618 | 2/20 | 0.84 |
| ▸ | CRHBP | P24387 | 1/20 | 0.84 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.84 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.75 |
| ▸ | HCAR3 | P49019 | 5/20 | 0.74 |
| ▸ | LMNA | P02545 | 1/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.64 |
| ▸ | POLB | P06746 | 2/20 | 0.64 |
| ▸ | PRSS1 | P07477 | 4/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15321333 | 0.99 | MAPT (0.82) | MAPTALDH1A1RAB9ANPC1PKM | |
| SCHEMBL9192588 | 0.90 | HCAR3 (0.77) | MAPTALDH1A1RAB9ANPC1PKM | |
| SCHEMBL25998804 | 0.89 | ALDH1A1 (0.67) | MAPTALDH1A1RAB9ANPC1PKM | |
| SCHEMBL15774665 | 0.88 | MAPT (0.87) | MAPTALDH1A1RAB9ANPC1PKM | |
| SCHEMBL7972061 | 0.87 | MAPT (0.75) | MAPTALDH1A1RAB9ANPC1PKM | |
| SCHEMBL22382354 | 0.86 | MAPT (0.81) | MAPTALDH1A1RAB9ANPC1PKM | |
| SCHEMBL15412105 | 0.86 | HCAR3 (0.64) | MAPTALDH1A1RAB9ANPC1PKM | |
| SCHEMBL1964842 | 0.86 | MAPT (1.00) | MAPTALDH1A1RAB9ANPC1PKM | |
| SCHEMBL6044024 | 0.85 | HCAR3 (1.00) | MAPTALDH1A1RAB9ANPC1PKM | |
| SCHEMBL22382490 | 0.85 | MAPT (0.78) | MAPTALDH1A1RAB9ANPC1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0480204-B1 | Imidazole derivatives, potent and selective antagonists of angiotensin II receptor | FUJISAWA PHARMACEUTICAL CO (JP) | 1996-03-20 | — | — | EP | disclosed |
| US-5215994-A | Treating or preventing hypertension or heart failure | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-06-01 | — | — | US | disclosed |
| US-5210092-A | Hypotensive agents | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-05-11 | — | — | US | disclosed |
| EP-0480204-A1 | Imidazole derivatives, potent and selective antagonists of angiotensin II receptor | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-04-15 | — | — | EP | disclosed |