Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 5/20 | 0.77 |
| ▸ | MAPT | P10636 | 3/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.68 |
| ▸ | RAB9A | P51151 | 2/20 | 0.68 |
| ▸ | NPC1 | O15118 | 2/20 | 0.68 |
| ▸ | PKM | P14618 | 2/20 | 0.68 |
| ▸ | CRHBP | P24387 | 1/20 | 0.68 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.68 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.64 |
| ▸ | PRSS1 | P07477 | 4/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5315342 | 0.91 | MAPT (0.81) | HCAR3MAPTALDH1A1RAB9ANPC1 | |
| SCHEMBL9043097 | 0.90 | MAPT (0.84) | HCAR3MAPTALDH1A1RAB9ANPC1 | |
| SCHEMBL9195511 | 0.90 | HCAR3 (0.62) | HCAR3MAPTALDH1A1RAB9ANPC1 | |
| SCHEMBL15321333 | 0.89 | MAPT (0.82) | HCAR3MAPTALDH1A1RAB9ANPC1 | |
| SCHEMBL19436444 | 0.89 | PRSS1 (0.64) | HCAR3MAPTALDH1A1RAB9ANPC1 | |
| SCHEMBL6044024 | 0.87 | HCAR3 (1.00) | HCAR3MAPTALDH1A1RAB9ANPC1 | |
| SCHEMBL11242963 | 0.86 | HCAR3 (0.97) | HCAR3MAPTALDH1A1RAB9ANPC1 | |
| SCHEMBL763439 | 0.86 | HCAR3 (0.62) | HCAR3MAPTALDH1A1RAB9ANPC1 | |
| SCHEMBL11208444 | 0.86 | HCAR3 (0.97) | HCAR3MAPTALDH1A1RAB9ANPC1 | |
| SCHEMBL6044600 | 0.86 | HCAR3 (0.97) | HCAR3MAPTALDH1A1RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0425921-B1 | Benzimidazole derivatives, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1995-08-09 | — | — | EP | disclosed |
| US-5250554-A | Cardiovascular disorders | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1993-10-05 | — | — | US | disclosed |
| US-5128356-A | Angiotensin antagonist; cardiovascular disorders | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1992-07-07 | — | — | US | disclosed |
| EP-0425921-A1 | Benzimidazole derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1991-05-08 | — | — | EP | disclosed |