Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 1/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | NAMPT | P43490 | 3/20 | 0.33 |
| ▸ | GSK3A | P49840 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | KDM6B | O15054 | 1/20 | 0.31 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16452796 | 0.81 | NPC1 (0.46) | CYP2D6ALDH1A1CYP1A2CYP2C19GSK3A | |
| SCHEMBL18417278 | 0.78 | GSK3A (0.40) | PDE3BPDE3ANAMPTGSK3AGSK3B | |
| SCHEMBL5139855 | 0.77 | ALDH1A1 (0.50) | CYP2D6ALDH1A1CYP1A2CYP2C19NAMPT | |
| SCHEMBL29687292 | 0.77 | ALDH1A1 (0.50) | CYP2D6ALDH1A1CYP1A2CYP2C19NAMPT | |
| SCHEMBL20952966 | 0.76 | PDE3B (0.40) | PDE3BPDE3AGSK3BNPC1HPGD | |
| SCHEMBL21210897 | 0.70 | ALDH1A1 (0.53) | CYP2D6ALDH1A1CYP1A2CYP2C19NAMPT | |
| SCHEMBL23583896 | 0.66 | ALDH1A1 (0.60) | CYP2D6ALDH1A1CYP1A2CYP2C19NAMPT | |
| SCHEMBL30138428 | 0.66 | CYP2D6 (0.46) | CYP2D6ALDH1A1CYP2C19NAMPTNPC1 | |
| SCHEMBL30138409 | 0.65 | HCAR3 (0.45) | ALDH1A1HPGDTSHR | |
| SCHEMBL4871445 | 0.65 | ALDH1A1 (0.40) | CYP2D6ALDH1A1CYP1A2CYP2C19NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0480155-B1 | 4-Substituted dihydropyrido (4,3-d)pyrimidines as analgesics and topical antiinflammatory agents for the treatment of skin disorders | HOECHST ROUSSEL PHARMA (US) | 1996-01-31 | — | — | EP | claimed |
| EP-0480155-A2 | 4-Substituted dihydropyrido (4,3-d)pyrimidines as analgesics and topical antiinflammatory agents for the treatment of skin disorders | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1992-04-15 | — | — | EP | claimed |
| US-5059602-A | 4-substituted dihydropyrido(4,3-d)pyrimidines as analgesics and topical antiinflammatory agents for the treatment of skin disorders | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1991-10-22 | — | — | US | claimed |
| EP-0480155-B1 | 4-Substituted dihydropyrido (4,3-d)pyrimidines as analgesics and topical antiinflammatory agents for the treatment of skin disorders | HOECHST ROUSSEL PHARMA (US) | 1996-01-31 | — | — | EP | disclosed |
| EP-0480155-A2 | 4-Substituted dihydropyrido (4,3-d)pyrimidines as analgesics and topical antiinflammatory agents for the treatment of skin disorders | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1992-04-15 | — | — | EP | disclosed |
| US-5095019-A | 4-substituted dihydropyrido(4,3-D)pyrimidines as analgesics and topical antiinflammatory agents for the treatment of skin disorders | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1992-03-10 | — | — | US | disclosed |
| US-5059602-A | 4-substituted dihydropyrido(4,3-d)pyrimidines as analgesics and topical antiinflammatory agents for the treatment of skin disorders | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1991-10-22 | — | — | US | disclosed |