Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | EDNRA | P25101 | 3/20 | 0.43 |
| ▸ | EDNRB | P24530 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.41 |
| ▸ | CRHBP | P24387 | 1/20 | 0.41 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | BRD2 | P25440 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9493265 | 0.90 | KMT2A (0.46) | ALDH1A1GAAEDNRAMAPTSMN1; SMN2 | |
| SCHEMBL9047803 | 0.88 | PKM (0.55) | ALDH1A1EDNRAMAPTTP53LMNA | |
| SCHEMBL9045052 | 0.83 | MEN1 (0.55) | ALDH1A1EDNRAEDNRBMAPTKMT2A | |
| SCHEMBL9491423 | 0.80 | EDNRA (0.43) | ALDH1A1EDNRAEDNRBMAPTKMT2A | |
| SCHEMBL9046709 | 0.80 | ALDH1A1 (0.60) | ALDH1A1EDNRAEDNRBMAPTKMT2A | |
| SCHEMBL9052684 | 0.80 | EDNRA (0.68) | EDNRAEDNRB | |
| SCHEMBL6785011 | 0.79 | EDNRA (0.67) | ALDH1A1EDNRAEDNRBMAPTLMNA | |
| SCHEMBL9044020 | 0.78 | EDNRA (0.42) | ALDH1A1EDNRAEDNRBMAPTKMT2A | |
| SCHEMBL7304221 | 0.78 | ALDH1A1 (0.41) | ALDH1A1GAATSHREDNRAEDNRB | |
| SCHEMBL9044797 | 0.78 | RXFP1 (0.54) | LMNARXFP1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0510526-B1 | Use of sulfonamides as drug and new sulfonamides | HOFFMANN LA ROCHE (CH) | 1996-12-04 | — | — | EP | disclosed |
| US-5270313-A | Treatment of circulatory disorders | HOFFMANN-LA ROCHE INC. (US) | 1993-12-14 | — | — | US | disclosed |
| EP-0510526-A1 | Use of sulfonamides as drug and new sulfonamides | F.HOFFMANN-LA ROCHE & CO. AKTIENGESELLSCHAFT (CH) | 1992-10-28 | — | — | EP | disclosed |