Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.54 |
| ▸ | SLC22A12 | Q96S37 | 5/20 | 0.48 |
| ▸ | KDM1A | O60341 | 1/20 | 0.47 |
| ▸ | PTGDR2 | Q9Y5Y4 | 11/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.44 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.44 |
| ▸ | SLC22A11 | Q9NSA0 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9491248 | 0.91 | KDM1A (0.57) | RXFP1SLC22A12KDM1APTGDR2CYP2C9 | |
| SCHEMBL9047803 | 0.85 | PKM (0.55) | RXFP1KDM1ALMNAPOLBHTT | |
| SCHEMBL9491423 | 0.82 | EDNRA (0.43) | RXFP1 | |
| SCHEMBL9045613 | 0.82 | EDNRA (0.66) | — | |
| SCHEMBL9044020 | 0.80 | EDNRA (0.42) | RXFP1 | |
| SCHEMBL9045181 | 0.80 | EDNRA (0.59) | KDM1A | |
| SCHEMBL7974338 | 0.79 | EDNRA (0.41) | RXFP1 | |
| SCHEMBL9045052 | 0.79 | MEN1 (0.55) | KDM1A | |
| SCHEMBL9043154 | 0.78 | ALDH1A1 (0.44) | RXFP1LMNAHTT | |
| SCHEMBL9493265 | 0.78 | KMT2A (0.46) | RXFP1LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0510526-B1 | Use of sulfonamides as drug and new sulfonamides | HOFFMANN LA ROCHE (CH) | 1996-12-04 | — | — | EP | disclosed |
| US-5270313-A | Treatment of circulatory disorders | HOFFMANN-LA ROCHE INC. (US) | 1993-12-14 | — | — | US | disclosed |
| EP-0510526-A1 | Use of sulfonamides as drug and new sulfonamides | F.HOFFMANN-LA ROCHE & CO. AKTIENGESELLSCHAFT (CH) | 1992-10-28 | — | — | EP | disclosed |