SCHEMBL9043244

SCHEMBL9043244

CCCCc1nc2c(C)ccnc2n1Cc1ccc(-n2c(Br)ccc2C#N)cc1

nearest known ligand 0.45

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
AGTR2 P50052 2/20 0.43
AGTR1 P30556 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9040891 0.94 AGTR2 (0.49) AGTR2AGTR1
SCHEMBL9043376 0.93 AGTR2 (0.47) AGTR2AGTR1
SCHEMBL9043129 0.91 AGTR2 (0.45) AGTR2AGTR1
SCHEMBL9041604 0.90 AGTR2 (0.44) AGTR2AGTR1
SCHEMBL9043353 0.90 AGTR2 (0.42) AGTR2AGTR1
SCHEMBL9041772 0.89 AGTR2 (0.40) AGTR2AGTR1
SCHEMBL9040869 0.89 AGTR2 (0.39) AGTR2AGTR1
SCHEMBL9042199 0.86 AGTR1 (0.35) AGTR2AGTR1
SCHEMBL9042679 0.85 AGTR2 (0.50) AGTR2AGTR1
SCHEMBL9043444 0.84 AGTR2 (0.42) AGTR2AGTR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0480204-B1 Imidazole derivatives, potent and selective antagonists of angiotensin II receptor FUJISAWA PHARMACEUTICAL CO (JP) 1996-03-20 EP disclosed
US-5215994-A Treating or preventing hypertension or heart failure FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1993-06-01 US disclosed
US-5210092-A Hypotensive agents FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1993-05-11 US disclosed