Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 2/20 | 0.35 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.35 |
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
| ▸ | NOS2 | P35228 | 1/20 | 0.33 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9043244 | 0.86 | AGTR2 (0.43) | AGTR1AGTR2 | |
| SCHEMBL9041470 | 0.81 | AGTR1 (0.36) | AGTR1AGTR2NOS1NOS2 | |
| SCHEMBL9040869 | 0.81 | AGTR2 (0.39) | AGTR1AGTR2 | |
| SCHEMBL9040891 | 0.81 | AGTR2 (0.49) | AGTR1AGTR2 | |
| SCHEMBL9043353 | 0.80 | AGTR2 (0.42) | AGTR1AGTR2 | |
| SCHEMBL9041772 | 0.80 | AGTR2 (0.40) | AGTR1AGTR2 | |
| SCHEMBL9043376 | 0.79 | AGTR2 (0.47) | AGTR1AGTR2 | |
| SCHEMBL9854218 | 0.77 | AGTR1 (0.44) | AGTR1AGTR2KDM4EALDH1A1LMNA | |
| SCHEMBL9043129 | 0.77 | AGTR2 (0.45) | AGTR1AGTR2 | |
| SCHEMBL9041604 | 0.76 | AGTR2 (0.44) | AGTR1AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0480204-B1 | Imidazole derivatives, potent and selective antagonists of angiotensin II receptor | FUJISAWA PHARMACEUTICAL CO (JP) | 1996-03-20 | — | — | EP | disclosed |
| US-5215994-A | Treating or preventing hypertension or heart failure | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-06-01 | — | — | US | disclosed |
| US-5210092-A | Hypotensive agents | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-05-11 | — | — | US | disclosed |