Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 6/20 | 0.54 |
| ▸ | EDNRB | P24530 | 2/20 | 0.52 |
| ▸ | EDNRA | P25101 | 2/20 | 0.52 |
| ▸ | PGR | P06401 | 4/20 | 0.50 |
| ▸ | FBP1 | P09467 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 3/20 | 0.46 |
| ▸ | CCR4 | P51679 | 1/20 | 0.46 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.45 |
| ▸ | KIT | P10721 | 1/20 | 0.45 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.45 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | TEK | Q02763 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9047048 | 0.88 | EDNRB (0.52) | KDM1AEDNRBEDNRAFBP1MAOA | |
| SCHEMBL9492250 | 0.86 | KDM1A (0.59) | KDM1AEDNRBEDNRACCR4SLC40A1 | |
| SCHEMBL9044255 | 0.84 | ALDH1A1 (0.56) | KDM1AEDNRBEDNRAFBP1PTPN2 | |
| SCHEMBL9047067 | 0.84 | EDNRB (0.59) | KDM1AEDNRBEDNRAFBP1MAOA | |
| SCHEMBL9046070 | 0.83 | EDNRB (0.53) | EDNRBEDNRAKITTSHR | |
| SCHEMBL9046709 | 0.81 | ALDH1A1 (0.60) | KDM1AEDNRBEDNRAMAOAKIT | |
| SCHEMBL9044114 | 0.81 | EDNRA (0.47) | EDNRBEDNRACCR4SLC40A1TSHR | |
| SCHEMBL9495682 | 0.81 | EDNRB (0.59) | EDNRBEDNRAFBP1KITKDM4E | |
| SCHEMBL9045764 | 0.81 | EDNRB (0.59) | EDNRBEDNRAFBP1KITKDM4E | |
| SCHEMBL9043560 | 0.81 | EDNRA (0.59) | KDM1AEDNRBEDNRACCR4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0510526-B1 | Use of sulfonamides as drug and new sulfonamides | HOFFMANN LA ROCHE (CH) | 1996-12-04 | — | — | EP | disclosed |
| US-5270313-A | Treatment of circulatory disorders | HOFFMANN-LA ROCHE INC. (US) | 1993-12-14 | — | — | US | disclosed |
| EP-0510526-A1 | Use of sulfonamides as drug and new sulfonamides | F.HOFFMANN-LA ROCHE & CO. AKTIENGESELLSCHAFT (CH) | 1992-10-28 | — | — | EP | disclosed |