Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | EDNRB | P24530 | 2/20 | 0.52 |
| ▸ | EDNRA | P25101 | 2/20 | 0.52 |
| ▸ | FBP1 | P09467 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.47 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.46 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.45 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.45 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9045384 | 0.91 | ALDH1A1 (0.54) | ALDH1A1MEN1KMT2AHPGDSMN1; SMN2 | |
| SCHEMBL9047067 | 0.85 | EDNRB (0.59) | ALDH1A1MEN1KMT2AEDNRBEDNRA | |
| SCHEMBL9044301 | 0.84 | KDM1A (0.54) | EDNRBEDNRAFBP1TSHRKDM4E | |
| SCHEMBL9045266 | 0.83 | EDNRA (0.79) | ALDH1A1MEN1KMT2AHPGDSMN1; SMN2 | |
| SCHEMBL9046070 | 0.82 | EDNRB (0.53) | ALDH1A1MEN1KMT2ASMN1; SMN2EDNRB | |
| SCHEMBL9046378 | 0.81 | EDNRA (0.57) | ALDH1A1MEN1KMT2AEDNRBEDNRA | |
| SCHEMBL9043560 | 0.81 | EDNRA (0.59) | ALDH1A1MEN1KMT2ASMN1; SMN2EDNRB | |
| SCHEMBL9046709 | 0.81 | ALDH1A1 (0.60) | ALDH1A1MEN1KMT2AEDNRBEDNRA | |
| SCHEMBL9495682 | 0.81 | EDNRB (0.59) | ALDH1A1MEN1KMT2AEDNRBEDNRA | |
| SCHEMBL9045764 | 0.81 | EDNRB (0.59) | ALDH1A1MEN1KMT2AEDNRBEDNRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0510526-B1 | Use of sulfonamides as drug and new sulfonamides | HOFFMANN LA ROCHE (CH) | 1996-12-04 | — | — | EP | disclosed |
| US-5270313-A | Treatment of circulatory disorders | HOFFMANN-LA ROCHE INC. (US) | 1993-12-14 | — | — | US | disclosed |
| EP-0510526-A1 | Use of sulfonamides as drug and new sulfonamides | F.HOFFMANN-LA ROCHE & CO. AKTIENGESELLSCHAFT (CH) | 1992-10-28 | — | — | EP | disclosed |