Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.42 |
| ▸ | PRKCI | P41743 | 1/20 | 0.41 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.41 |
| ▸ | FLT1 | P17948 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | NQO2 | P16083 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9041316 | 0.78 | EPHX1 (0.45) | NPC1RAB9ATP53SMN1; SMN2LMNA | |
| SCHEMBL9043728 | 0.77 | HSD11B1 (0.41) | LMNAKMT2AMEN1 | |
| SCHEMBL9044489 | 0.76 | CNR2 (0.52) | ALDH1A1KDM4EHPGDNPSR1 | |
| SCHEMBL19474859 | 0.75 | KMT2A (0.69) | TP53LMNAGAADEGS1ALDH1A1 | |
| SCHEMBL9043610 | 0.74 | CNR2 (0.38) | ALDH1A1KMT2AKDM4EMEN1HPGD | |
| SCHEMBL9125076 | 0.73 | KMT2A (0.57) | NPC1RAB9ALMNAGAAP2RX1 | |
| SCHEMBL1070529 | 0.71 | HTT (0.50) | NPC1RAB9ASMN1; SMN2ROCK2ROCK1 | |
| SCHEMBL8261428 | 0.70 | GAA (0.85) | TP53SMN1; SMN2LMNAL3MBTL1GAA | |
| SCHEMBL9307980 | 0.69 | KDM4C (0.56) | SMN1; SMN2L3MBTL1GAAALDH1A1KMT2A | |
| SCHEMBL9127816 | 0.69 | ABCG2 (0.55) | NPC1RAB9ATP53SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0578419-B1 | Pyridine derivatives and pharmaceutical compositions containing them | KYOWA HAKKO KOGYO KK (JP) | 1996-09-04 | — | — | EP | disclosed |
| US-5374634-A | Treating osteoporosis | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1994-12-20 | — | — | US | disclosed |
| EP-0578419-A1 | Pyridine derivatives and pharmaceutical compositions containing them | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1994-01-12 | — | — | EP | disclosed |