Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 15/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | KDM6B | O15054 | 9/20 | 0.49 |
| ▸ | KDM4D | Q6B0I6 | 6/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | KDM4A | O75164 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.47 |
| ▸ | CFTR | P13569 | 1/20 | 0.47 |
| ▸ | GOPC | Q9HD26 | 1/20 | 0.47 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.41 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21056807 | 0.83 | KDM4C (0.58) | KDM4CALDH1A1KMT2ATDP1KDM6B | |
| SCHEMBL9305621 | 0.83 | KDM4E (0.53) | KDM4CALDH1A1KMT2ATDP1GAA | |
| SCHEMBL9042891 | 0.82 | LMNA (0.45) | KDM4CALDH1A1KMT2ATDP1GAA | |
| SCHEMBL28704416 | 0.81 | KDM4C (0.51) | KDM4CALDH1A1KMT2ATDP1KDM6B | |
| SCHEMBL30772293 | 0.79 | KDM4E (0.49) | KDM4CALDH1A1KMT2ATDP1GAA | |
| SCHEMBL8945914 | 0.77 | ALDH1A1 (0.79) | ALDH1A1KMT2ATDP1GAAKDM4E | |
| SCHEMBL29248918 | 0.77 | ALDH1A1 (0.45) | KDM4CALDH1A1KMT2ATDP1GAA | |
| SCHEMBL17294252 | 0.77 | KDM4C (0.53) | KDM4CALDH1A1KMT2ATDP1GAA | |
| SCHEMBL17465921 | 0.77 | KDM4C (0.53) | KDM4CALDH1A1KMT2ATDP1GAA | |
| SCHEMBL29219093 | 0.74 | KDM4C (0.50) | KDM4CALDH1A1KMT2ATDP1KDM6B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5369084-A | Isonicotinic acid derivatives and related spiro compounds with herbicidal action | JANSSEN PHARMACEUTICAL N.V. (BE) | 1994-11-29 | — | — | US | disclosed |
| EP-0558521-A1 | ISONICOTINIC ACID DERIVATIVES AND RELATED SPIRO COMPOUNDS WITH HERBICIDAL ACTION | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-09-08 | — | — | EP | disclosed |
| WO-1992009577-A1 | ISONICOTINIC ACID DERIVATIVES AND RELATED SPIRO COMPOUNDS WITH HERBICIDAL ACTION | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-06-11 | — | — | WO | disclosed |