Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 4/20 | 0.45 |
| ▸ | EDNRB | P24530 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CCR2 | P41597 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9046198 | 0.89 | KMT2A (0.55) | EDNRAEDNRBALDH1A1POLBFFAR4 | |
| SCHEMBL9044505 | 0.89 | ALDH1A1 (0.44) | EDNRAEDNRBALDH1A1POLBTSHR | |
| SCHEMBL9045035 | 0.85 | EDNRA (0.61) | EDNRAEDNRBALDH1A1TSHRKMT2A | |
| SCHEMBL9045459 | 0.82 | ALDH1A1 (0.47) | EDNRAEDNRBALDH1A1POLBTSHR | |
| SCHEMBL9044456 | 0.79 | EDNRA (0.61) | EDNRAEDNRBKMT2AMEN1 | |
| SCHEMBL1748339 | 0.77 | IDO1 (0.42) | ALDH1A1KDM4ELMNA | |
| SCHEMBL9046333 | 0.77 | MAPT (0.45) | EDNRAALDH1A1KMT2AMEN1RXFP1 | |
| SCHEMBL9045980 | 0.75 | MEN1 (0.47) | EDNRAEDNRBALDH1A1POLBTSHR | |
| SCHEMBL9047760 | 0.75 | EDNRA (0.42) | EDNRAEDNRBALDH1A1POLBKMT2A | |
| SCHEMBL9044533 | 0.74 | EDNRA (0.40) | EDNRAEDNRBALDH1A1POLBTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0510526-B1 | Use of sulfonamides as drug and new sulfonamides | HOFFMANN LA ROCHE (CH) | 1996-12-04 | — | — | EP | disclosed |
| US-5270313-A | Treatment of circulatory disorders | HOFFMANN-LA ROCHE INC. (US) | 1993-12-14 | — | — | US | disclosed |
| EP-0510526-A1 | Use of sulfonamides as drug and new sulfonamides | F.HOFFMANN-LA ROCHE & CO. AKTIENGESELLSCHAFT (CH) | 1992-10-28 | — | — | EP | disclosed |