Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.64 |
| ▸ | HPGD | P15428 | 1/20 | 0.64 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.64 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.56 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.56 |
| ▸ | SNCA | P37840 | 1/20 | 0.55 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.54 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9044613 | 1.00 | KDM4E (0.64) | KDM4ESMN1; SMN2ALDH1A1HPGDALOX15 | |
| SCHEMBL13956393 | 0.88 | POLB (0.49) | KDM4ESMN1; SMN2ALDH1A1HPGDALOX15 | |
| SCHEMBL30558537 | 0.86 | BACE1 (0.58) | KDM4ESMN1; SMN2ALDH1A1HPGDALOX15 | |
| SCHEMBL17368762 | 0.86 | BACE1 (0.58) | KDM4ESMN1; SMN2ALDH1A1HPGDALOX15 | |
| SCHEMBL17361604 | 0.86 | BACE1 (0.58) | KDM4ESMN1; SMN2ALDH1A1HPGDALOX15 | |
| SCHEMBL17361606 | 0.86 | BACE1 (0.58) | KDM4ESMN1; SMN2ALDH1A1HPGDALOX15 | |
| Malonic Acid SCHEMBL27751245 | 0.83 | NFE2L2 (0.61) | KDM4ESMN1; SMN2ALDH1A1HPGDALOX15 | |
| SCHEMBL5146748 | 0.82 | PTGS1 (0.63) | KDM4ESMN1; SMN2HPGDNFE2L2POLB | |
| SCHEMBL9046973 | 0.82 | HTR1A (0.63) | KDM4EALDH1A1HPGDHSD17B10ABCG2 | |
| SCHEMBL9046978 | 0.82 | HTR1A (0.63) | KDM4EALDH1A1HPGDHSD17B10ABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0344577-B1 | Butenoic or propenoic acid derivatives | EISAI CO LTD (JP) | 1996-10-09 | — | — | EP | disclosed |
| EP-0344577-A2 | Butenoic or propenoic acid derivatives | Eisai Co., Ltd. (JP) | 1989-12-06 | — | — | EP | disclosed |