Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.43 |
| ▸ | HPGD | P15428 | 7/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | STAT3 | P40763 | 1/20 | 0.31 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8084270 | 0.91 | HSD17B10 (0.53) | KDM4EHPGDHSD17B10ALDH1A1PMP22 | |
| SCHEMBL9048740 | 0.90 | ADRB2 (0.40) | KDM4EHPGDHSD17B10ALDH1A1ADRB2 | |
| SCHEMBL9043731 | 0.88 | KDM4E (0.33) | KDM4EHPGDHSD17B10ALDH1A1PMP22 | |
| SCHEMBL9046354 | 0.87 | KDM4E (0.44) | KDM4EHPGDHSD17B10ALDH1A1BRD4 | |
| SCHEMBL9047922 | 0.86 | KDM4E (0.46) | KDM4EHPGDHSD17B10ALDH1A1PMP22 | |
| SCHEMBL9046791 | 0.85 | ALDH1A1 (0.43) | KDM4EHPGDHSD17B10ALDH1A1ADRB2 | |
| SCHEMBL8906725 | 0.84 | KDM4E (0.45) | KDM4EHPGDHSD17B10ALDH1A1CYP2C19 | |
| SCHEMBL9047030 | 0.84 | KDM4E (0.46) | KDM4EHPGDHSD17B10ALDH1A1 | |
| SCHEMBL9095828 | 0.82 | KCNH2 (0.48) | KDM4EHPGDHSD17B10ALDH1A1ADRB2 | |
| SCHEMBL8091409 | 0.81 | KDM4E (0.40) | KDM4EHPGDHSD17B10ALDH1A1PMP22 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0588166-B1 | Antibacterial 7-isoindolinyl-quinolone and naphthyridone derivatives | BAYER AG (DE) | 1996-06-05 | — | — | EP | disclosed |
| EP-0588166-A2 | Antibacterial 7-isoindolinyl-quinolone and naphthyridone derivatives | BAYER AG (DE) | 1994-03-23 | — | — | EP | disclosed |