Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.39 |
| ▸ | TOP2A | P11388 | 4/20 | 0.36 |
| ▸ | TOP2B | Q02880 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.36 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | CLK2 | P49760 | 1/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9046791 | 0.94 | ALDH1A1 (0.43) | ADRB2KCNH2KDM4EALDH1A1HPGD | |
| SCHEMBL9043731 | 0.91 | KDM4E (0.33) | ADRB2KCNH2KDM4EALDH1A1HPGD | |
| SCHEMBL9095828 | 0.91 | KCNH2 (0.48) | ADRB2KCNH2TOP2ATOP2BKDM4E | |
| SCHEMBL9044779 | 0.90 | KDM4E (0.43) | ADRB2KCNH2KDM4EALDH1A1HPGD | |
| SCHEMBL9046294 | 0.90 | MEN1 (0.42) | ADRB2KCNH2TOP2ATOP2BKDM4E | |
| SCHEMBL9044987 | 0.89 | KDM4E (0.39) | KCNH2TOP2ATOP2BKDM4EALDH1A1 | |
| SCHEMBL9047130 | 0.89 | ADRB2 (0.39) | ADRB2KCNH2TOP2ATOP2BKDM4E | |
| SCHEMBL9049171 | 0.89 | KCNH2 (0.34) | ADRB2KCNH2TOP2ATOP2B | |
| SCHEMBL9049573 | 0.88 | KCNH2 (0.40) | ADRB2KCNH2TOP2ATOP2BKDM4E | |
| SCHEMBL9045493 | 0.88 | KDM4E (0.44) | TOP2ATOP2BKDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0588166-B1 | Antibacterial 7-isoindolinyl-quinolone and naphthyridone derivatives | BAYER AG (DE) | 1996-06-05 | — | — | EP | disclosed |
| EP-0588166-A2 | Antibacterial 7-isoindolinyl-quinolone and naphthyridone derivatives | BAYER AG (DE) | 1994-03-23 | — | — | EP | disclosed |