Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.33 |
| ▸ | AMPD1 | P23109 | 1/20 | 0.33 |
| ▸ | AMPD2 | Q01433 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9047324 | 1.00 | KMT2A (0.37) | KMT2APOLBHDAC6HDAC1AMPD1 | |
| SCHEMBL9047978 | 0.99 | KMT2A (0.36) | KMT2APOLBHDAC6HDAC1AMPD1 | |
| SCHEMBL9045286 | 0.90 | ADORA1 (0.32) | AMPD1AMPD2ADORA1 | |
| SCHEMBL9341443 | 0.90 | ADORA1 (0.32) | AMPD1AMPD2ADORA1 | |
| SCHEMBL9045224 | 0.90 | ADORA1 (0.32) | AMPD1AMPD2ADORA1 | |
| SCHEMBL9047700 | 0.86 | KMT2A (0.34) | KMT2APOLBHDAC6HDAC1CA12 | |
| SCHEMBL9047706 | 0.86 | KMT2A (0.34) | KMT2APOLBHDAC6HDAC1CA12 | |
| SCHEMBL9045922 | 0.85 | TAS1R3 (0.35) | CA12CA1CA2CA9 | |
| SCHEMBL9045503 | 0.84 | CYP1A2 (0.33) | KMT2APOLBCA12CA1CA2 | |
| SCHEMBL9777813 | 0.83 | ALDH1A1 (0.34) | CA12CA1CA2CA9ADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0432677-B1 | N-(pyrrolo[2,3-d]pyrimidin-3-ylacyl)-glutamic acid derivatives | UNIV PRINCETON (US) | 1996-03-06 | — | — | EP | disclosed |
| US-5344932-A | N-(pyrrolo(2,3-d)pyrimidin-3-ylacyl)-glutamic acid derivatives | TRUSTEES OF PRINCETON UNIVERSITY (US) | 1994-09-06 | — | — | US | disclosed |
| US-5248775-A | Pyrrolo(2,3-d)pyrimidines | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1993-09-28 | — | — | US | disclosed |
| US-5028608-A | Antineoplastic Agents | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1991-07-02 | — | — | US | disclosed |
| EP-0432677-A1 | N-(pyrrolo[2,3-d]pyrimidin-3-ylacyl)-glutamic acid derivatives | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1991-06-19 | — | — | EP | disclosed |