Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.53 |
| ▸ | NPC1 | O15118 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | STAT3 | P40763 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | MAP2K4 | P45985 | 2/20 | 0.45 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
| ▸ | FLT3 | P36888 | 1/20 | 0.44 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | IDO1 | P14902 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | ALPL | P05186 | 1/20 | 0.43 |
| ▸ | TTK | P33981 | 1/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.43 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1563249 | 0.88 | KDM4E (0.50) | KDM4ENPC1ALDH1A1RAB9ATP53 | |
| SCHEMBL28377216 | 0.82 | CYP1A2 (0.50) | KDM4ENPC1ALDH1A1RAB9ATP53 | |
| SCHEMBL28377726 | 0.79 | CYP1A2 (0.47) | KDM4ENPC1ALDH1A1RAB9ATP53 | |
| SCHEMBL25863815 | 0.78 | CYP1A2 (0.61) | KDM4ENPC1ALDH1A1RAB9ATP53 | |
| SCHEMBL6236381 | 0.77 | LMNA (0.53) | KDM4EALDH1A1CYP1A2MAPK1SMN1; SMN2 | |
| SCHEMBL5908296 | 0.75 | KDM4E (0.57) | KDM4ENPC1ALDH1A1RAB9ATP53 | |
| SCHEMBL5820415 | 0.73 | KDM4E (0.53) | KDM4ECYP1A2STAT3HIF1AMAP2K4 | |
| SCHEMBL14698771 | 0.73 | KDM4E (0.49) | KDM4ENPC1ALDH1A1RAB9ATP53 | |
| SCHEMBL5820414 | 0.72 | CNR1 (0.54) | KDM4ENPC1ALDH1A1RAB9ASTAT3 | |
| SCHEMBL9041896 | 0.72 | CYP1A2 (0.61) | KDM4ENPC1ALDH1A1RAB9ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0613470-B1 | NOVEL 4-CINNOLINONE DERIVATIVES, THEIR PREPARATION AND APPLICATION IN THERAPY | PF MEDICAMENT (FR) | 1996-01-10 | — | — | EP | claimed |
| EP-0519140-A1 | Method for the preparation of substituted 1,4-dihydro-4-oxo-cinnoline-3-carboxylic acid, esters and salts thereof, and intermediates used in their preparation | HYBRINOVA (FR) | 1992-12-23 | — | — | EP | disclosed |