Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.51 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.51 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.51 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | CDC42 | P60953 | 1/20 | 0.51 |
| ▸ | RAC1 | P63000 | 1/20 | 0.51 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | PLAU | P00749 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9592161 | 1.00 | KDM4E (0.62) | KDM4ECYP1A2ALDH1A1HPGDCYP2C19 | |
| SCHEMBL9529778 | 1.00 | KDM4E (0.62) | KDM4ECYP1A2ALDH1A1HPGDCYP2C19 | |
| SCHEMBL16346363 | 0.86 | KDM4E (0.66) | KDM4ECYP1A2ALDH1A1HPGDCYP2C19 | |
| SCHEMBL10415359 | 0.85 | ALDH1A1 (0.49) | KDM4ECYP1A2ALDH1A1HPGDCYP2C19 | |
| SCHEMBL9593388 | 0.85 | KDM4E (0.64) | KDM4ECYP1A2ALDH1A1HPGDCYP2C19 | |
| SCHEMBL9196872 | 0.85 | KDM4E (0.64) | KDM4ECYP1A2ALDH1A1HPGDCYP2C19 | |
| SCHEMBL585274 | 0.84 | ALDH1A1 (0.66) | CYP1A2ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL10710104 | 0.84 | ALDH1A1 (0.48) | KDM4ECYP1A2ALDH1A1HSD17B10CYP2C9 | |
| SCHEMBL9046301 | 0.83 | KDM4E (0.62) | KDM4ECYP1A2ALDH1A1HPGDCYP2C19 | |
| SCHEMBL9592745 | 0.83 | KDM4E (0.62) | KDM4ECYP1A2ALDH1A1HPGDCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 59 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0203557-B1 | PROCESS FOR THE PREPARATION OF (6-METHOXY-2-NAPHTHYL)-(1-BROMOETHYL)-KETONE AND ITS DERIVATIVES | ZAMBON S.p.A. (IT) | 1989-04-19 | — | — | EP | claimed |
| US-4748256-A | Process for the preparation of (6-methoxy-2-naphthyl)-(1-bromoethyl)-ketone and its derivatives | ZAMBON SPA (IT) | 1988-05-31 | — | — | US | claimed |
| US-4328356-A | Process for preparing esters of arylacetic acids from alpha-halo-alkylarylketones | MONTEDISON S.P.A. (IT) | 1982-05-04 | — | — | US | claimed |
| EP-0035305-B2 | Process for preparing esters of 2-(6'-methoxy-2'-naphtyl)-propionic acid via rearrangement of new ketals of 2-halo-1-(6'-methoxy-2'-naphtyl)-propan-1-one | BLASCHIM SPA (IT) | 1996-09-04 | — | — | EP | disclosed |
| EP-0273316-B1 | STEREOCONVERGENT PROCESS FOR PREPARING OPTICALLY ACTIVE CARBOXYLIC ACIDS | ZAMBON S.p.A. (IT) | 1993-07-28 | — | — | EP | disclosed |
| US-5210258-A | Optically active alpha-naththylalkyl ketones | SYNTEX PHARMACEUTICALS INTERNATIONAL LTD. (BM) | 1993-05-11 | — | — | US | disclosed |
| US-5084569-A | TRIOXY BICYCLIC COMPOUNDS USEFUL FOR PREPARING OPTICALLY ACTIVE CARBOXYLIC ACIDS | ZAMBON SPA (IT) | 1992-01-28 | — | — | US | disclosed |
| EP-0217376-B1 | PROCESS FOR PREPARING OPTICALLY ACTIVE ALPHA-HALOALKYL-ARYLKETONES | ZAMBON S.p.A. (IT) | 1990-09-12 | — | — | EP | disclosed |
| US-4922009-A | Stereoconvergent process for preparing optically active carboxylic acids | ZAMBON SPA (IT) | 1990-05-01 | — | — | US | disclosed |
| US-4912254-A | Preparation of α-arylalkanoic acids | SYNTEX PHARMACEUTICAL INTERNATIONAL LIMITED (BM) | 1990-03-27 | — | — | US | disclosed |
| US-4902799-A | HYPOTENSIVE, HYPOLIPEMIC, ANTIANOXIC, SPASMOLYTIC, PLATELET AGGREGATION INHIBITING, ANTITHROMBOTIC, CALCIUM ANTAGONIZING, NEUROLEPTIC AGENTS | MAGGIONI-WINTHROP S.P.A. (IT) | 1990-02-20 | — | — | US | disclosed |
| EP-0081993-A2 | Optically active alpha-substituted aryl ketones, their preparation and their use in preparing alpha-arylalkanoic acids | SYNTEX PHARMACEUTICALS INTERNATIONAL LIMITED (BM) | 1983-06-22 | — | — | EP | disclosed |
| EP-0071299-A1 | Process for preparing alkanoic acids or esters thereof by rearrangement of alpha-halo-ketones in protic medium and in the presence of a non-noble metal salt | BLASCHIM S.p.A. (IT) | 1983-02-09 | — | — | EP | disclosed |
| EP-0064394-A1 | Manufacture of alpha-arylalkanoic acids and precursors | SYNTEX PHARMACEUTICALS INTERNATIONAL LIMITED (BM) | 1982-11-10 | — | — | EP | disclosed |
| US-4328356-A | Process for preparing esters of arylacetic acids from alpha-halo-alkylarylketones | MONTEDISON S.P.A. (IT) | 1982-05-04 | — | — | US | disclosed |
| US-4327022-A | Heterocyclic alkyl naphthols | STERLING DRUG INC. (US) | 1982-04-27 | — | — | US | disclosed |
| EP-0048136-A2 | Process for preparing alpha-aromatic group substituted alkanoic acids or esters thereof | SYNTEX PHARMACEUTICALS INTERNATIONAL LIMITED (BM) | 1982-03-24 | — | — | EP | disclosed |
| EP-0035305-A2 | Process for preparing esters of 2-(6'-methoxy-2'-naphtyl)-propionic acid via rearrangement of new ketals of 2-halo-1-(6'-methoxy-2'-naphtyl)-propan-1-one | BLASCHIM S.p.A. (IT) | 1981-09-09 | — | — | EP | disclosed |
| EP-0034871-A2 | Process for preparing esters of alkanoic acids via rearrangement of alpha-haloketals | BLASCHIM S.p.A. (IT) | 1981-09-02 | — | — | EP | disclosed |
| US-4169108-A | 5(OR 6)-[(Substituted-amino)alkyl]-2,3-naphthalenediols | STERLING DRUG INC. (US) | 1979-09-25 | — | — | US | disclosed |