Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 2/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | DRD4 | P21917 | 7/20 | 0.48 |
| ▸ | DRD2 | P14416 | 7/20 | 0.48 |
| ▸ | DRD3 | P35462 | 6/20 | 0.48 |
| ▸ | HTR1A | P08908 | 2/20 | 0.48 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.48 |
| ▸ | DRD1 | P21728 | 2/20 | 0.48 |
| ▸ | HTR2A | P28223 | 2/20 | 0.48 |
| ▸ | HTR7 | P34969 | 2/20 | 0.48 |
| ▸ | HRH1 | P35367 | 2/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.48 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.48 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.48 |
| ▸ | HTR1D | P28221 | 1/20 | 0.48 |
| ▸ | HTR1B | P28222 | 1/20 | 0.48 |
| ▸ | HTR2C | P28335 | 1/20 | 0.48 |
| ▸ | HTR1E | P28566 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9044372 | 0.80 | PIK3CA (0.57) | DRD4DRD2DRD3HTR1AADRA2C | |
| SCHEMBL9044375 | 0.80 | DRD2 (0.55) | DRD4DRD2DRD3HTR1AADRA2C | |
| SCHEMBL27738088 | 0.78 | DRD2 (0.63) | SLC6A2SLC6A4DRD4DRD2DRD3 | |
| SCHEMBL9045494 | 0.78 | DRD2 (0.60) | DRD4DRD2DRD3HTR1AADRA2C | |
| SCHEMBL9527094 | 0.77 | DRD4 (0.47) | SLC6A2SLC6A4ALDH1A1DRD4DRD2 | |
| SCHEMBL9631388 | 0.76 | DRD2 (0.63) | SLC6A2SLC6A4DRD4DRD2DRD3 | |
| SCHEMBL9045733 | 0.74 | MAPT (0.51) | ALDH1A1HTR1APOLBKCNH2 | |
| SCHEMBL9044175 | 0.73 | DRD2 (0.56) | SLC6A2SLC6A4DRD4DRD2DRD3 | |
| SCHEMBL8908080 | 0.73 | DRD2 (0.67) | ALDH1A1DRD4DRD2DRD3HTR1A | |
| SCHEMBL9046833 | 0.72 | POLB (0.49) | SLC6A2ALDH1A1DRD4DRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0556329-B1 | SUBSTITUTED PIPERAZINES AS CENTRAL NERVOUS SYSTEM AGENTS | WARNER LAMBERT CO (US) | 1996-01-10 | — | — | EP | claimed |
| EP-0556329-A1 | SUBSTITUTED PIPERAZINES AS CENTRAL NERVOUS SYSTEM AGENTS. | WARNER LAMBERT CO (US) | 1993-08-25 | — | — | EP | claimed |
| WO-1992007832-A2 | SUBSTITUTED PIPERAZINES AS CENTRAL NERVOUS SYSTEM AGENTS | WARNER-LAMBERT COMPANY (US) | 1992-05-14 | — | — | WO | claimed |
| EP-0556329-B1 | SUBSTITUTED PIPERAZINES AS CENTRAL NERVOUS SYSTEM AGENTS | WARNER LAMBERT CO (US) | 1996-01-10 | — | — | EP | disclosed |
| US-5270312-A | Substituted piperazines as central nervous system agents | WARNER-LAMBERT COMPANY (US) | 1993-12-14 | — | — | US | disclosed |
| EP-0556329-A1 | SUBSTITUTED PIPERAZINES AS CENTRAL NERVOUS SYSTEM AGENTS. | WARNER LAMBERT CO (US) | 1993-08-25 | — | — | EP | disclosed |
| WO-1993006092-A1 | PIPERAZINYL (SULFONYL)AMIDE DERIVATIVES OF CAMPHOR AS OXYTOCIN ANTAGONISTS | MERCK & CO., INC. (US) | 1993-04-01 | — | — | WO | disclosed |
| WO-1992007832-A2 | SUBSTITUTED PIPERAZINES AS CENTRAL NERVOUS SYSTEM AGENTS | WARNER-LAMBERT COMPANY (US) | 1992-05-14 | — | — | WO | disclosed |