Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.55 |
| ▸ | DRD4 | P21917 | 4/20 | 0.55 |
| ▸ | DRD3 | P35462 | 3/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | HTR1A | P08908 | 3/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.47 |
| ▸ | DRD1 | P21728 | 1/20 | 0.47 |
| ▸ | DRD5 | P21918 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | HTR7 | P34969 | 1/20 | 0.47 |
| ▸ | HRH1 | P35367 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9044833 | 0.86 | DRD2 (0.55) | DRD2DRD4DRD3HTR1ADRD1 | |
| SCHEMBL9044372 | 0.84 | PIK3CA (0.57) | DRD2DRD4DRD3POLBHTR1A | |
| SCHEMBL27738088 | 0.82 | DRD2 (0.63) | DRD2DRD4DRD3POLBHTR1A | |
| SCHEMBL9045494 | 0.82 | DRD2 (0.60) | DRD2DRD4DRD3POLBHTR1A | |
| SCHEMBL9045017 | 0.80 | SLC6A2 (0.49) | DRD2DRD4DRD3POLBHTR1A | |
| SCHEMBL9045733 | 0.80 | MAPT (0.51) | POLBHTR1AKCNH2 | |
| SCHEMBL9044624 | 0.79 | DRD4 (0.52) | DRD2DRD4DRD3HTR1AHTR2A | |
| SCHEMBL9044175 | 0.77 | DRD2 (0.56) | DRD2DRD4DRD3POLBHTR1A | |
| SCHEMBL9631372 | 0.77 | POLB (0.78) | DRD2DRD4DRD3POLBHTR1A | |
| SCHEMBL9046833 | 0.76 | POLB (0.49) | DRD2DRD4DRD3POLBHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0556329-B1 | SUBSTITUTED PIPERAZINES AS CENTRAL NERVOUS SYSTEM AGENTS | WARNER LAMBERT CO (US) | 1996-01-10 | — | — | EP | claimed |
| EP-0556329-A1 | SUBSTITUTED PIPERAZINES AS CENTRAL NERVOUS SYSTEM AGENTS. | WARNER LAMBERT CO (US) | 1993-08-25 | — | — | EP | claimed |
| WO-1992007832-A2 | SUBSTITUTED PIPERAZINES AS CENTRAL NERVOUS SYSTEM AGENTS | WARNER-LAMBERT COMPANY (US) | 1992-05-14 | — | — | WO | claimed |
| EP-0556329-B1 | SUBSTITUTED PIPERAZINES AS CENTRAL NERVOUS SYSTEM AGENTS | WARNER LAMBERT CO (US) | 1996-01-10 | — | — | EP | disclosed |
| US-5270312-A | Substituted piperazines as central nervous system agents | WARNER-LAMBERT COMPANY (US) | 1993-12-14 | — | — | US | disclosed |
| EP-0556329-A1 | SUBSTITUTED PIPERAZINES AS CENTRAL NERVOUS SYSTEM AGENTS. | WARNER LAMBERT CO (US) | 1993-08-25 | — | — | EP | disclosed |
| WO-1992007832-A2 | SUBSTITUTED PIPERAZINES AS CENTRAL NERVOUS SYSTEM AGENTS | WARNER-LAMBERT COMPANY (US) | 1992-05-14 | — | — | WO | disclosed |