Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | BCHE | P06276 | 2/20 | 0.50 |
| ▸ | ACHE | P22303 | 2/20 | 0.50 |
| ▸ | BACE1 | P56817 | 2/20 | 0.50 |
| ▸ | GRM5 | P41594 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.46 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9045640 | 0.86 | MAPT (0.51) | MAPTGAAKDM4EPOLBBCHE | |
| SCHEMBL27738088 | 0.83 | DRD2 (0.63) | POLBHTR1ALMNA | |
| SCHEMBL9045494 | 0.83 | DRD2 (0.60) | POLBHTR1AKCNH2 | |
| SCHEMBL9044375 | 0.80 | DRD2 (0.55) | POLBHTR1AKCNH2 | |
| SCHEMBL7954746 | 0.78 | MAPT (0.68) | MAPTGAAKDM4EPOLBBCHE | |
| SCHEMBL28070725 | 0.78 | HTR1A (0.60) | MAPTGAAKDM4EPOLBBCHE | |
| SCHEMBL9044372 | 0.78 | PIK3CA (0.57) | POLBHTR1AKCNH2 | |
| SCHEMBL1127229 | 0.76 | KMT2A (0.66) | MAPTGAAKDM4EPOLBBCHE | |
| SCHEMBL11001791 | 0.74 | POLB (0.64) | MAPTGAAKDM4EPOLBACHE | |
| SCHEMBL312815 | 0.74 | KCNH2 (0.59) | POLBHTR1AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0556329-B1 | SUBSTITUTED PIPERAZINES AS CENTRAL NERVOUS SYSTEM AGENTS | WARNER LAMBERT CO (US) | 1996-01-10 | — | — | EP | claimed |
| EP-0556329-A1 | SUBSTITUTED PIPERAZINES AS CENTRAL NERVOUS SYSTEM AGENTS. | WARNER LAMBERT CO (US) | 1993-08-25 | — | — | EP | claimed |
| WO-1992007832-A2 | SUBSTITUTED PIPERAZINES AS CENTRAL NERVOUS SYSTEM AGENTS | WARNER-LAMBERT COMPANY (US) | 1992-05-14 | — | — | WO | claimed |
| EP-0556329-B1 | SUBSTITUTED PIPERAZINES AS CENTRAL NERVOUS SYSTEM AGENTS | WARNER LAMBERT CO (US) | 1996-01-10 | — | — | EP | disclosed |
| US-5270312-A | Substituted piperazines as central nervous system agents | WARNER-LAMBERT COMPANY (US) | 1993-12-14 | — | — | US | disclosed |
| EP-0556329-A1 | SUBSTITUTED PIPERAZINES AS CENTRAL NERVOUS SYSTEM AGENTS. | WARNER LAMBERT CO (US) | 1993-08-25 | — | — | EP | disclosed |
| WO-1992007832-A2 | SUBSTITUTED PIPERAZINES AS CENTRAL NERVOUS SYSTEM AGENTS | WARNER-LAMBERT COMPANY (US) | 1992-05-14 | — | — | WO | disclosed |