Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 7/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.70 |
| ▸ | DRD3 | P35462 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.55 |
| ▸ | HPGD | P15428 | 4/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | BRD4 | O60885 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.53 |
| ▸ | PIM1 | P11309 | 1/20 | 0.53 |
| ▸ | GSK3A | P49840 | 1/20 | 0.53 |
| ▸ | GSK3B | P49841 | 1/20 | 0.53 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9048236 | 0.90 | TOP1 (0.71) | TOP1ALDH1A1DRD3KDM4EHPGD | |
| Hydrochloric Acid SCHEMBL8571733 | 0.89 | TOP1 (0.70) | TOP1ALDH1A1DRD3KDM4EHPGD | |
| SCHEMBL30626291 | 0.89 | ALDH1A1 (0.71) | TOP1ALDH1A1DRD3KDM4EHPGD | |
| SCHEMBL9750142 | 0.85 | ALDH1A1 (0.69) | TOP1ALDH1A1DRD3KDM4EHPGD | |
| SCHEMBL9045127 | 0.84 | TOP1 (0.61) | TOP1ALDH1A1DRD3KDM4EHPGD | |
| SCHEMBL5571927 | 0.84 | ALDH1A1 (0.71) | TOP1ALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL5571931 | 0.84 | ALDH1A1 (0.71) | TOP1ALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL5571992 | 0.84 | ALDH1A1 (0.71) | TOP1ALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL2854967 | 0.83 | ALDH1A1 (0.72) | TOP1ALDH1A1DRD3KDM4EHPGD | |
| SCHEMBL2856476 | 0.83 | ALDH1A1 (0.82) | ALDH1A1DRD3KDM4EHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0360258-B1 | Amino acid quinoline and naphthyridine derivatives | ABBOTT LAB (US) | 1996-08-14 | — | — | EP | disclosed |
| US-5057523-A | Water soluble bactericide | ABBOTT LABORATORIES (US) | 1991-10-15 | — | — | US | disclosed |
| EP-0360258-A2 | Amino acid quinoline and naphthyridine derivatives | ABBOTT LABORATORIES (US) | 1990-03-28 | — | — | EP | disclosed |