Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.82 |
| ▸ | DRD3 | P35462 | 1/20 | 0.69 |
| ▸ | MEN1 | O00255 | 6/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.63 |
| ▸ | HPGD | P15428 | 4/20 | 0.63 |
| ▸ | NPC1 | O15118 | 1/20 | 0.63 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.62 |
| ▸ | LMNA | P02545 | 3/20 | 0.61 |
| ▸ | HTT | P42858 | 3/20 | 0.61 |
| ▸ | TSHR | P16473 | 2/20 | 0.61 |
| ▸ | BRD4 | O60885 | 1/20 | 0.61 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | RAD52 | P43351 | 1/20 | 0.57 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.56 |
| ▸ | USP2 | O75604 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29388444 | 0.90 | ALDH1A1 (1.00) | ALDH1A1DRD3MEN1KMT2AKDM4E | |
| SCHEMBL7809357 | 0.90 | ALDH1A1 (1.00) | ALDH1A1DRD3MEN1KMT2AKDM4E | |
| SCHEMBL28334653 | 0.87 | ALDH1A1 (0.78) | ALDH1A1DRD3MEN1KMT2AKDM4E | |
| SCHEMBL10915570 | 0.87 | ALDH1A1 (0.80) | ALDH1A1DRD3MEN1KMT2AKDM4E | |
| Hydrochloric Acid SCHEMBL11023756 | 0.86 | ALDH1A1 (0.79) | ALDH1A1DRD3MEN1KMT2AKDM4E | |
| SCHEMBL2854967 | 0.85 | ALDH1A1 (0.72) | ALDH1A1DRD3MEN1KMT2AKDM4E | |
| SCHEMBL9045019 | 0.83 | TOP1 (0.71) | ALDH1A1DRD3MEN1KMT2AKDM4E | |
| SCHEMBL9667689 | 0.83 | ALDH1A1 (0.72) | ALDH1A1DRD3MEN1KMT2AKDM4E | |
| SCHEMBL15282135 | 0.83 | ALDH1A1 (0.86) | ALDH1A1DRD3MEN1KMT2AKDM4E | |
| SCHEMBL11391733 | 0.83 | ALDH1A1 (0.86) | ALDH1A1DRD3MEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100273787-A1 | KYNURENINE-AMINOTRANSFERASE INHIBITORS | UNIVERSITY OF MARYLAND, BALTIMORE | 2010-10-28 | — | — | US | claimed |
| EP-2222662-A2 | KYNURENINE-AMINOTRANSFERASE INHIBITORS | University of Maryland, Baltimore (US) | 2010-09-01 | — | — | EP | claimed |
| WO-2009064836-A2 | KYNURENINE-AMINOTRANSFERASE INHIBITORS | UNIVERSITY OF MARYLAND, BALTIMORE (US) | 2009-05-22 | — | — | WO | claimed |
| US-20100273787-A1 | KYNURENINE-AMINOTRANSFERASE INHIBITORS | UNIVERSITY OF MARYLAND, BALTIMORE | 2010-10-28 | — | — | US | disclosed |
| EP-2222662-A2 | KYNURENINE-AMINOTRANSFERASE INHIBITORS | University of Maryland, Baltimore (US) | 2010-09-01 | — | — | EP | disclosed |
| WO-2009064836-A2 | KYNURENINE-AMINOTRANSFERASE INHIBITORS | UNIVERSITY OF MARYLAND, BALTIMORE (US) | 2009-05-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100273787-A1 | KYNURENINE-AMINOTRANSFERASE INHIBITORS | KYNU, AADAT, KMO | ALDH1A1 616/4885DRD3 1261/4885MEN1 3452/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.