SCHEMBL9045171

SCHEMBL9045171

CS/C(=C\[N+](=O)[O-])N(C)Cc1ccc(Cl)nc1

nearest known ligand 0.56

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
AGTR2 P50052 1/20 0.39
CHRNB2 P17787 2/20 0.39
CHRNA4 P43681 2/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
ALDH1A1 P00352 5/20 0.38
MAPT P10636 2/20 0.38
CYP3A4 P08684 1/20 0.38
CYP2D6 P10635 1/20 0.38
CYP2C9 P11712 1/20 0.38
CYP2C19 P33261 1/20 0.38
RXFP1 Q9HBX9 1/20 0.38
CHRNA1 P02708 1/20 0.37
CHRNA3 P32297 1/20 0.37
CHRNA7 P36544 1/20 0.37
HTT P42858 1/20 0.36
MEN1 O00255 1/20 0.36
KMT2A Q03164 1/20 0.36
CASP6 P55212 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7660230 1.00 AGTR2 (0.39) AGTR2CHRNB2CHRNA4SMN1; SMN2ALDH1A1
SCHEMBL888516 0.86 CHRNB2 (0.38) CHRNB2CHRNA4SMN1; SMN2ALDH1A1MAPT
SCHEMBL888515 0.86 CHRNB2 (0.38) CHRNB2CHRNA4SMN1; SMN2ALDH1A1MAPT
SCHEMBL7670556 0.85 MMP2 (0.34) ALDH1A1MAPTHTT
SCHEMBL7662760 0.85 SMN1; SMN2 (0.37) AGTR2CHRNB2CHRNA4SMN1; SMN2ALDH1A1
SCHEMBL7660296 0.84 CHRNB2 (0.36) CHRNB2CHRNA4SMN1; SMN2ALDH1A1MAPT
SCHEMBL7753165 0.84 CHRNB2 (0.41) CHRNB2CHRNA4SMN1; SMN2ALDH1A1MAPT
SCHEMBL7672435 0.84 CHRNB2 (0.41) CHRNB2CHRNA4SMN1; SMN2ALDH1A1MAPT
SCHEMBL7752527 0.82 CHRNB2 (0.40) CHRNB2CHRNA4SMN1; SMN2ALDH1A1MAPT
SCHEMBL7660053 0.82 CHRNB2 (0.40) CHRNB2CHRNA4SMN1; SMN2ALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0366085-B1 Tetrahydropyrimidines, their production and use TAKEDA CHEMICAL INDUSTRIES LTD (JP) 1996-04-17 EP disclosed
EP-0366085-A2 Tetrahydropyrimidines, their production and use Takeda Chemical Industries, Ltd. (JP) 1990-05-02 EP disclosed