Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 5/20 | 0.59 |
| ▸ | EDNRB | P24530 | 5/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | KIT | P10721 | 2/20 | 0.46 |
| ▸ | KDM1A | O60341 | 1/20 | 0.46 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.45 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.44 |
| ▸ | CDK1 | P06493 | 1/20 | 0.44 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.44 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
| ▸ | CDK7 | P50613 | 1/20 | 0.44 |
| ▸ | CCNH | P51946 | 1/20 | 0.44 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.44 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9045067 | 0.91 | EDNRA (0.70) | EDNRAEDNRBMEN1KMT2ATDP1 | |
| SCHEMBL9045084 | 0.91 | EDNRA (0.70) | EDNRAEDNRBMEN1KMT2ATDP1 | |
| SCHEMBL9045052 | 0.91 | MEN1 (0.55) | EDNRAEDNRBMEN1KMT2ATDP1 | |
| SCHEMBL6785011 | 0.90 | EDNRA (0.67) | EDNRAEDNRBMEN1KMT2AALDH1A1 | |
| SCHEMBL9046552 | 0.89 | EDNRA (0.57) | EDNRAEDNRBMEN1KMT2ATDP1 | |
| SCHEMBL9494268 | 0.88 | EDNRA (0.56) | EDNRAEDNRBMEN1KMT2ATDP1 | |
| SCHEMBL9045149 | 0.87 | NPSR1 (0.51) | EDNRAEDNRBMEN1KMT2ATDP1 | |
| SCHEMBL9046709 | 0.87 | ALDH1A1 (0.60) | EDNRAEDNRBMEN1KMT2AALDH1A1 | |
| SCHEMBL9044998 | 0.86 | PTGDR2 (0.52) | EDNRAEDNRBMEN1KMT2ATDP1 | |
| SCHEMBL7721651 | 0.85 | EDNRA (0.64) | EDNRAEDNRBMEN1KMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0510526-B1 | Use of sulfonamides as drug and new sulfonamides | HOFFMANN LA ROCHE (CH) | 1996-12-04 | — | — | EP | disclosed |
| US-5270313-A | Treatment of circulatory disorders | HOFFMANN-LA ROCHE INC. (US) | 1993-12-14 | — | — | US | disclosed |
| EP-0510526-A1 | Use of sulfonamides as drug and new sulfonamides | F.HOFFMANN-LA ROCHE & CO. AKTIENGESELLSCHAFT (CH) | 1992-10-28 | — | — | EP | disclosed |