Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 5/20 | 0.57 |
| ▸ | EDNRB | P24530 | 5/20 | 0.57 |
| ▸ | KDM1A | O60341 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | KIT | P10721 | 3/20 | 0.42 |
| ▸ | MMP1 | P03956 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP3 | P08254 | 1/20 | 0.41 |
| ▸ | MMP7 | P09237 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | OXTR | P30559 | 1/20 | 0.40 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.40 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9045520 | 0.91 | EDNRA (0.51) | EDNRAEDNRBMEN1KMT2AKIT | |
| SCHEMBL9045181 | 0.89 | EDNRA (0.59) | EDNRAEDNRBKDM1AMEN1KMT2A | |
| SCHEMBL9045067 | 0.89 | EDNRA (0.70) | EDNRAEDNRBKDM1AMEN1KMT2A | |
| SCHEMBL9045084 | 0.89 | EDNRA (0.70) | EDNRAEDNRBKDM1AMEN1KMT2A | |
| SCHEMBL9046378 | 0.88 | EDNRA (0.57) | EDNRAEDNRBKDM1AMEN1KMT2A | |
| SCHEMBL9046700 | 0.86 | EDNRA (0.49) | EDNRAEDNRBKDM1AMEN1KMT2A | |
| SCHEMBL9494268 | 0.86 | EDNRA (0.56) | EDNRAEDNRBKDM1AMEN1KMT2A | |
| SCHEMBL9043808 | 0.85 | EDNRB (0.47) | EDNRAEDNRBMEN1KMT2AKIT | |
| SCHEMBL9047883 | 0.83 | EDNRA (0.45) | EDNRAEDNRBMEN1KMT2AKIT | |
| SCHEMBL9047430 | 0.83 | EDNRA (0.47) | EDNRAEDNRBKDM1AKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0510526-B1 | Use of sulfonamides as drug and new sulfonamides | HOFFMANN LA ROCHE (CH) | 1996-12-04 | — | — | EP | disclosed |
| US-5270313-A | Treatment of circulatory disorders | HOFFMANN-LA ROCHE INC. (US) | 1993-12-14 | — | — | US | disclosed |
| EP-0510526-A1 | Use of sulfonamides as drug and new sulfonamides | F.HOFFMANN-LA ROCHE & CO. AKTIENGESELLSCHAFT (CH) | 1992-10-28 | — | — | EP | disclosed |