Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.52 |
| ▸ | CNR1 | P21554 | 1/20 | 0.51 |
| ▸ | CNR2 | P34972 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | PDE1A | P54750 | 1/20 | 0.49 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | PDE4A | P27815 | 1/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | FEN1 | P39748 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9044689 | 0.95 | LMNA (0.55) | MEN1KMT2ANPC1RAB9AKDM4E | |
| SCHEMBL9046658 | 0.93 | ALDH1A1 (0.63) | MEN1KMT2ANPC1RAB9AKDM4E | |
| SCHEMBL3517727 | 0.86 | MEN1 (0.57) | MEN1KMT2ANPC1RAB9AKDM4E | |
| SCHEMBL9044523 | 0.85 | CNR1 (0.51) | MEN1KMT2AKDM4EALDH1A1LMNA | |
| SCHEMBL9045112 | 0.85 | FEN1 (0.51) | NPC1RAB9AKDM4EALDH1A1LMNA | |
| SCHEMBL9046400 | 0.84 | TP53 (0.48) | KDM4EALDH1A1LMNACNR1CNR2 | |
| SCHEMBL9046763 | 0.84 | EGFR (0.55) | MEN1KMT2ANPC1RAB9AKDM4E | |
| SCHEMBL2409456 | 0.84 | PDE1A (0.51) | NPC1RAB9AALDH1A1CNR1CNR2 | |
| SCHEMBL24054529 | 0.82 | MEN1 (0.71) | MEN1KMT2ANPC1RAB9AKDM4E | |
| SCHEMBL9043358 | 0.82 | RAB9A (0.60) | MEN1KMT2ANPC1RAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0452873-B1 | 1,8-Naphthyridin-2-one derivatives | KYOWA HAKKO KOGYO KK (JP) | 1996-07-03 | — | — | EP | disclosed |
| US-5126341-A | Treatment of rheumarthritis | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1992-06-30 | — | — | US | disclosed |
| EP-0452873-A1 | 1,8-Naphthyridin-2-one derivatives | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1991-10-23 | — | — | EP | disclosed |